Membrane
The invention relates to a therapeutic composition comprising an inner portion and a biocompatible membrane fully or partially surrounding the inner portion. The biocompatible membrane comprises at least two layers: a first layer of a porous, nonwoven network of thermoplastic polyurethane polymer fi...
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| creator | Brendan ROBB Teodor-Matei CIRSTEA Robert James MCKEAN |
| description | The invention relates to a therapeutic composition comprising an inner portion and a biocompatible membrane fully or partially surrounding the inner portion. The biocompatible membrane comprises at least two layers: a first layer of a porous, nonwoven network of thermoplastic polyurethane polymer fibers formed by electrospinning and having a porosity of greater than or equal to 50%; an average pore diameter of less than 5 μm; and has a thickness in the range 10 to 250 μm; and a second layer of a porous, nonwoven network of thermoplastic polymer fibers formed by electrospinning. The second layer has a mean average fiber diameter of the second layer is greater than the mean average fiber diameter in the first layer, and/or wherein the average pore diameter of the second layer is greater than the average pore diameter of the first layer. The inner portion comprises a therapeutic agent. The invention also relates to uses of the membrane and therapeutic composition, for instance, to encapsulate therapeutic cells. |
| format | Patent |
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The biocompatible membrane comprises at least two layers: a first layer of a porous, nonwoven network of thermoplastic polyurethane polymer fibers formed by electrospinning and having a porosity of greater than or equal to 50%; an average pore diameter of less than 5 μm; and has a thickness in the range 10 to 250 μm; and a second layer of a porous, nonwoven network of thermoplastic polymer fibers formed by electrospinning. The second layer has a mean average fiber diameter of the second layer is greater than the mean average fiber diameter in the first layer, and/or wherein the average pore diameter of the second layer is greater than the average pore diameter of the first layer. The inner portion comprises a therapeutic agent. The invention also relates to uses of the membrane and therapeutic composition, for instance, to encapsulate therapeutic cells.</description><language>eng ; heb</language><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210531&DB=EPODOC&CC=IL&NR=281735A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210531&DB=EPODOC&CC=IL&NR=281735A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Brendan ROBB</creatorcontrib><creatorcontrib>Teodor-Matei CIRSTEA</creatorcontrib><creatorcontrib>Robert James MCKEAN</creatorcontrib><title>Membrane</title><description>The invention relates to a therapeutic composition comprising an inner portion and a biocompatible membrane fully or partially surrounding the inner portion. The biocompatible membrane comprises at least two layers: a first layer of a porous, nonwoven network of thermoplastic polyurethane polymer fibers formed by electrospinning and having a porosity of greater than or equal to 50%; an average pore diameter of less than 5 μm; and has a thickness in the range 10 to 250 μm; and a second layer of a porous, nonwoven network of thermoplastic polymer fibers formed by electrospinning. The second layer has a mean average fiber diameter of the second layer is greater than the mean average fiber diameter in the first layer, and/or wherein the average pore diameter of the second layer is greater than the average pore diameter of the first layer. The inner portion comprises a therapeutic agent. The invention also relates to uses of the membrane and therapeutic composition, for instance, to encapsulate therapeutic cells.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZODwTc1NKkrMS-VhYE1LzClO5YXS3Axybq4hzh66qQX58anFBYnJqXmpJfGePkYWhubGpo7GBBUAANHWGuw</recordid><startdate>20210531</startdate><enddate>20210531</enddate><creator>Brendan ROBB</creator><creator>Teodor-Matei CIRSTEA</creator><creator>Robert James MCKEAN</creator><scope>EVB</scope></search><sort><creationdate>20210531</creationdate><title>Membrane</title><author>Brendan ROBB ; Teodor-Matei CIRSTEA ; Robert James MCKEAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_IL281735A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; heb</language><creationdate>2021</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Brendan ROBB</creatorcontrib><creatorcontrib>Teodor-Matei CIRSTEA</creatorcontrib><creatorcontrib>Robert James MCKEAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Brendan ROBB</au><au>Teodor-Matei CIRSTEA</au><au>Robert James MCKEAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Membrane</title><date>2021-05-31</date><risdate>2021</risdate><abstract>The invention relates to a therapeutic composition comprising an inner portion and a biocompatible membrane fully or partially surrounding the inner portion. The biocompatible membrane comprises at least two layers: a first layer of a porous, nonwoven network of thermoplastic polyurethane polymer fibers formed by electrospinning and having a porosity of greater than or equal to 50%; an average pore diameter of less than 5 μm; and has a thickness in the range 10 to 250 μm; and a second layer of a porous, nonwoven network of thermoplastic polymer fibers formed by electrospinning. The second layer has a mean average fiber diameter of the second layer is greater than the mean average fiber diameter in the first layer, and/or wherein the average pore diameter of the second layer is greater than the average pore diameter of the first layer. The inner portion comprises a therapeutic agent. The invention also relates to uses of the membrane and therapeutic composition, for instance, to encapsulate therapeutic cells.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; heb |
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| title | Membrane |
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