Oligonucleotide and nucleic acid synthesis

Oligonucleotide and nucleic acid synthesis

The present invention relates to methods for the high fidelity synthesis of oligonucleotides and polynucleotides on a solid surface. In particular, the invention relates to methods of synthesising oligonucleotides, polynucleotides, and doublestranded polynucleotides/nucleic acids, such as DNA and XN...

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Hauptverfasser: PASCAL LANG, DANIEL BYGRAVE, MATTHEW HAYES, MATHEW JENISON, JOSEPH BRENNAN, CATHERINE FITZPATRICK, STUART CROSBY, IAIN BARLOW
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Sprache:eng ; heb
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creator PASCAL LANG
DANIEL BYGRAVE
MATTHEW HAYES
MATHEW JENISON
JOSEPH BRENNAN
CATHERINE FITZPATRICK
STUART CROSBY
IAIN BARLOW
description The present invention relates to methods for the high fidelity synthesis of oligonucleotides and polynucleotides on a solid surface. In particular, the invention relates to methods of synthesising oligonucleotides, polynucleotides, and doublestranded polynucleotides/nucleic acids, such as DNA and XNA, wherein the process comprises thermally controlled deprotection steps at the 5′-OH of previously coupled nucleosides or nucleotides at selected sites on the surface of the substrate.
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title Oligonucleotide and nucleic acid synthesis
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