N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use

N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use

wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic...

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Hauptverfasser: MAMMOLITI Oscar, ALVEY Luke Jonathan, MERAYO Nuria Merayo, NEWSOME Gregory John Robert, AKKARI Rhalid, GOSMINI Romain Luc Marie, BROWN Brian S, DE BLIECK Ann, COWART Marlon D, LEFRANCOIS Jean-Michel, MENET Christel Jeanne Marie, SWIFT Elizabeth C, JI Jianguo, PATEL Sachin V, PIZZONERO Mathieu Rafael, KYM Philip R, VAN DER PLAS Steven Emiel, CLAES Pieter Isabelle Roger, HOUSSEMAN Christopher Gaetan, GFESSER Gregory A, BOCK Xavier Marie, DESROY Nicolas, DE LEMOS Elsa, JANSEN Koen Karel, PALISSE Adeline Marie Elise, SHRESTHA Anurupa, WANG Xueqing, DUTHION Beranger
Format: Patent
Sprache:eng ; heb
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Zusammenfassung:wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).