An insulin conjugate using an immunoglobulin fragment

An insulin conjugate using an immunoglobulin fragment

The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insu...

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Hauptverfasser: SUNG MIN BAE, JAE HEE SHIN, SE CHANG KWON, YOUNG JIN PARK, DAE SEONG IM, DAE HAE SONG
Format: Patent
Sprache:eng ; heb
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creator SUNG MIN BAE
JAE HEE SHIN
SE CHANG KWON
YOUNG JIN PARK
DAE SEONG IM
DAE HAE SONG
description The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
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title An insulin conjugate using an immunoglobulin fragment
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