THIENOPYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE PREPARATION OF MEDICAMENTS
The invention relates to a compound of formula (1): in which R1 and R2 each independently represent a C1-6alkyl, C3-6alkenyl, C3-6cycloalkylC1-3alkyl or C3-6cycloalkyl; each of which is optionally substituted by 1 to 3 halogen atoms; R3 is isoxazolidin-2-ylcarbonyl or tetrahydroisoxazin-2-ylcarbonyl...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | RUKHSANA TASNEEM RASUL MARTIN EDWARD COOPER RACHEL HEULWEN REYNOLDS ANTHONY HOWARD INGALL SIMON DAVID GUILE |
| description | The invention relates to a compound of formula (1): in which R1 and R2 each independently represent a C1-6alkyl, C3-6alkenyl, C3-6cycloalkylC1-3alkyl or C3-6cycloalkyl; each of which is optionally substituted by 1 to 3 halogen atoms; R3 is isoxazolidin-2-ylcarbonyl or tetrahydroisoxazin-2-ylcarbonyl wherein each ring is optionally substituted by one hydroxy group; Q is -CO- or -C(R4)(R5)- in which R4 is a hydrogen atom or C1-4alkyl and R5 is a hydrogen atom or hydroxy group; and Ar is a 5- to 10-membered aromatic ring system in which up to 4 ring atoms may be heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification. It also relates to methods of preparing, pharmaceutical compositions containing and methods of using the compound of the formula (1), particularly in the modulation of autoimmune disease. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_IL159785A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>IL159785A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_IL159785A3</originalsourceid><addsrcrecordid>eNqFjTEKwkAQRdNYiHoFmQPEQkTUctlMzIA7s-yshVUIslaigXgDL24iKeysPu_zPn-avWNFyOIvgRwVxFiQMGoOPohFVSglQKyQQt-gN8HEXsjBivOiNIB-IZASHwfVgeFi3JwVgXiA3zlICa5_ssYhR51nk1tz79JizFm2LDHaapXaZ526trmmR3rVdFpvD7v91mz-Ch8lnTxc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>THIENOPYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE PREPARATION OF MEDICAMENTS</title><source>esp@cenet</source><creator>RUKHSANA TASNEEM RASUL ; MARTIN EDWARD COOPER ; RACHEL HEULWEN REYNOLDS ; ANTHONY HOWARD INGALL ; SIMON DAVID GUILE</creator><creatorcontrib>RUKHSANA TASNEEM RASUL ; MARTIN EDWARD COOPER ; RACHEL HEULWEN REYNOLDS ; ANTHONY HOWARD INGALL ; SIMON DAVID GUILE</creatorcontrib><description>The invention relates to a compound of formula (1): in which R1 and R2 each independently represent a C1-6alkyl, C3-6alkenyl, C3-6cycloalkylC1-3alkyl or C3-6cycloalkyl; each of which is optionally substituted by 1 to 3 halogen atoms; R3 is isoxazolidin-2-ylcarbonyl or tetrahydroisoxazin-2-ylcarbonyl wherein each ring is optionally substituted by one hydroxy group; Q is -CO- or -C(R4)(R5)- in which R4 is a hydrogen atom or C1-4alkyl and R5 is a hydrogen atom or hydroxy group; and Ar is a 5- to 10-membered aromatic ring system in which up to 4 ring atoms may be heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification. It also relates to methods of preparing, pharmaceutical compositions containing and methods of using the compound of the formula (1), particularly in the modulation of autoimmune disease.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20091118&DB=EPODOC&CC=IL&NR=159785A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20091118&DB=EPODOC&CC=IL&NR=159785A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RUKHSANA TASNEEM RASUL</creatorcontrib><creatorcontrib>MARTIN EDWARD COOPER</creatorcontrib><creatorcontrib>RACHEL HEULWEN REYNOLDS</creatorcontrib><creatorcontrib>ANTHONY HOWARD INGALL</creatorcontrib><creatorcontrib>SIMON DAVID GUILE</creatorcontrib><title>THIENOPYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE PREPARATION OF MEDICAMENTS</title><description>The invention relates to a compound of formula (1): in which R1 and R2 each independently represent a C1-6alkyl, C3-6alkenyl, C3-6cycloalkylC1-3alkyl or C3-6cycloalkyl; each of which is optionally substituted by 1 to 3 halogen atoms; R3 is isoxazolidin-2-ylcarbonyl or tetrahydroisoxazin-2-ylcarbonyl wherein each ring is optionally substituted by one hydroxy group; Q is -CO- or -C(R4)(R5)- in which R4 is a hydrogen atom or C1-4alkyl and R5 is a hydrogen atom or hydroxy group; and Ar is a 5- to 10-membered aromatic ring system in which up to 4 ring atoms may be heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification. It also relates to methods of preparing, pharmaceutical compositions containing and methods of using the compound of the formula (1), particularly in the modulation of autoimmune disease.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjTEKwkAQRdNYiHoFmQPEQkTUctlMzIA7s-yshVUIslaigXgDL24iKeysPu_zPn-avWNFyOIvgRwVxFiQMGoOPohFVSglQKyQQt-gN8HEXsjBivOiNIB-IZASHwfVgeFi3JwVgXiA3zlICa5_ssYhR51nk1tz79JizFm2LDHaapXaZ526trmmR3rVdFpvD7v91mz-Ch8lnTxc</recordid><startdate>20091118</startdate><enddate>20091118</enddate><creator>RUKHSANA TASNEEM RASUL</creator><creator>MARTIN EDWARD COOPER</creator><creator>RACHEL HEULWEN REYNOLDS</creator><creator>ANTHONY HOWARD INGALL</creator><creator>SIMON DAVID GUILE</creator><scope>EVB</scope></search><sort><creationdate>20091118</creationdate><title>THIENOPYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE PREPARATION OF MEDICAMENTS</title><author>RUKHSANA TASNEEM RASUL ; MARTIN EDWARD COOPER ; RACHEL HEULWEN REYNOLDS ; ANTHONY HOWARD INGALL ; SIMON DAVID GUILE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_IL159785A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2009</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>RUKHSANA TASNEEM RASUL</creatorcontrib><creatorcontrib>MARTIN EDWARD COOPER</creatorcontrib><creatorcontrib>RACHEL HEULWEN REYNOLDS</creatorcontrib><creatorcontrib>ANTHONY HOWARD INGALL</creatorcontrib><creatorcontrib>SIMON DAVID GUILE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RUKHSANA TASNEEM RASUL</au><au>MARTIN EDWARD COOPER</au><au>RACHEL HEULWEN REYNOLDS</au><au>ANTHONY HOWARD INGALL</au><au>SIMON DAVID GUILE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>THIENOPYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE PREPARATION OF MEDICAMENTS</title><date>2009-11-18</date><risdate>2009</risdate><abstract>The invention relates to a compound of formula (1): in which R1 and R2 each independently represent a C1-6alkyl, C3-6alkenyl, C3-6cycloalkylC1-3alkyl or C3-6cycloalkyl; each of which is optionally substituted by 1 to 3 halogen atoms; R3 is isoxazolidin-2-ylcarbonyl or tetrahydroisoxazin-2-ylcarbonyl wherein each ring is optionally substituted by one hydroxy group; Q is -CO- or -C(R4)(R5)- in which R4 is a hydrogen atom or C1-4alkyl and R5 is a hydrogen atom or hydroxy group; and Ar is a 5- to 10-membered aromatic ring system in which up to 4 ring atoms may be heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification. It also relates to methods of preparing, pharmaceutical compositions containing and methods of using the compound of the formula (1), particularly in the modulation of autoimmune disease.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_IL159785A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | THIENOPYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION, COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE PREPARATION OF MEDICAMENTS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T00%3A07%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=RUKHSANA%20TASNEEM%20RASUL&rft.date=2009-11-18&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EIL159785A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |