PROCESS FOR PRODUCING SULFONIMIDAMIDE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
This invention provides certain novel sulfonimidamide compounds wherein R is wherein A, B and C are as defined in claim 1; R is H, C1-C8 alkyl with the proviso that except for the isopropyl group there is no branching in the alpha-position, C3-C8 alkenyl, -(CH2)nOH wherein n is 1-5, -(CH2)pC6H5 wher...
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| creator | RAY,JAMES EDWARD TOTH,JOHN ELDON |
| description | This invention provides certain novel sulfonimidamide compounds wherein R is wherein A, B and C are as defined in claim 1; R is H, C1-C8 alkyl with the proviso that except for the isopropyl group there is no branching in the alpha-position, C3-C8 alkenyl, -(CH2)nOH wherein n is 1-5, -(CH2)pC6H5 wherein p is 1-3, or -C(O)R wherein Ris H or C1-C4 alkyl; R is H or -CH3; Z is -C(O)NR R or -C(OR )=NR wherein R is H or -CH3; R is wherein X is chlorine, bromine, iodine or -CH3; R is -C(O)R or a tautomer or pharmaceutically acceptable salt thereof. In addition, this invention encompasses formulations employing, processes of preparing, and methods of using these compounds as antineoplastic agents. |
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In addition, this invention encompasses formulations employing, processes of preparing, and methods of using these compounds as antineoplastic agents.</description><edition>5</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1994</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19940728&DB=EPODOC&CC=HU&NR=T65746A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19940728&DB=EPODOC&CC=HU&NR=T65746A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>RAY,JAMES EDWARD</creatorcontrib><creatorcontrib>TOTH,JOHN ELDON</creatorcontrib><title>PROCESS FOR PRODUCING SULFONIMIDAMIDE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM</title><description>This invention provides certain novel sulfonimidamide compounds wherein R is wherein A, B and C are as defined in claim 1; R is H, C1-C8 alkyl with the proviso that except for the isopropyl group there is no branching in the alpha-position, C3-C8 alkenyl, -(CH2)nOH wherein n is 1-5, -(CH2)pC6H5 wherein p is 1-3, or -C(O)R wherein Ris H or C1-C4 alkyl; R is H or -CH3; Z is -C(O)NR R or -C(OR )=NR wherein R is H or -CH3; R is wherein X is chlorine, bromine, iodine or -CH3; R is -C(O)R or a tautomer or pharmaceutically acceptable salt thereof. In addition, this invention encompasses formulations employing, processes of preparing, and methods of using these compounds as antineoplastic agents.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1994</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjL0KAjEQhNNYiPoKsi9gpZ71kmzMwl0S8nPtESRWogfn-2MEe4thBr6ZWYvig5MUI2gXoGWVJdsrxNxrZ3lghU0EigKPmHikCGgVeINhQEk5scS-DcljaNzZCNLZhGy_N8nQsBWre3ksdffzjdhrStIc6vya6jKXW33W92Ry6s6XU4fHv4UP3vEzcQ</recordid><startdate>19940728</startdate><enddate>19940728</enddate><creator>RAY,JAMES EDWARD</creator><creator>TOTH,JOHN ELDON</creator><scope>EVB</scope></search><sort><creationdate>19940728</creationdate><title>PROCESS FOR PRODUCING SULFONIMIDAMIDE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM</title><author>RAY,JAMES EDWARD ; TOTH,JOHN ELDON</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HUT65746A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1994</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>RAY,JAMES EDWARD</creatorcontrib><creatorcontrib>TOTH,JOHN ELDON</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>RAY,JAMES EDWARD</au><au>TOTH,JOHN ELDON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PRODUCING SULFONIMIDAMIDE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM</title><date>1994-07-28</date><risdate>1994</risdate><abstract>This invention provides certain novel sulfonimidamide compounds wherein R is wherein A, B and C are as defined in claim 1; R is H, C1-C8 alkyl with the proviso that except for the isopropyl group there is no branching in the alpha-position, C3-C8 alkenyl, -(CH2)nOH wherein n is 1-5, -(CH2)pC6H5 wherein p is 1-3, or -C(O)R wherein Ris H or C1-C4 alkyl; R is H or -CH3; Z is -C(O)NR R or -C(OR )=NR wherein R is H or -CH3; R is wherein X is chlorine, bromine, iodine or -CH3; R is -C(O)R or a tautomer or pharmaceutically acceptable salt thereof. In addition, this invention encompasses formulations employing, processes of preparing, and methods of using these compounds as antineoplastic agents.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PROCESS FOR PRODUCING SULFONIMIDAMIDE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
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