PROCESS FOR PRODUCING RAPAMYCIN DIMERS

A rapamycin dimer of general formula (1) (I) wherein A is -(CH2)n-, -(CH2)n-(CH=CH)-(CH2)m-, -(CH2)n-(-C 3BOND C-)-(CH2)m-, substituted alkyl, substituted alkenyl, substituted alkynyl, and substituted aromatic; n=1-10, m=1-10 and n=m or n NOTEQUAL m or a pharmaceutically acceptable salt thereof, whi...

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Hauptverfasser:	MUSSER,JOHN HENRY,US, VOGEL,ROBERT LEWIS,US, KAO,WENLING,US
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	MUSSER,JOHN HENRY,US VOGEL,ROBERT LEWIS,US KAO,WENLING,US
description	A rapamycin dimer of general formula (1) (I) wherein A is -(CH2)n-, -(CH2)n-(CH=CH)-(CH2)m-, -(CH2)n-(-C 3BOND C-)-(CH2)m-, substituted alkyl, substituted alkenyl, substituted alkynyl, and substituted aromatic; n=1-10, m=1-10 and n=m or n NOTEQUAL m or a pharmaceutically acceptable salt thereof, which is by virtue of its immunosuppressive activity is useful in treating transplantation rejection host vs. graft disease, autoimmune diseases, and diseases of inflammation.
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	PROCESS FOR PRODUCING RAPAMYCIN DIMERS
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