PROCESS FOR PRODUCING RAPAMYCIN DIMERS

A rapamycin dimer of general formula (1) (I) wherein A is -(CH2)n-, -(CH2)n-(CH=CH)-(CH2)m-, -(CH2)n-(-C 3BOND C-)-(CH2)m-, substituted alkyl, substituted alkenyl, substituted alkynyl, and substituted aromatic; n=1-10, m=1-10 and n=m or n NOTEQUAL m or a pharmaceutically acceptable salt thereof, whi...

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Bibliographische Detailangaben
Hauptverfasser:	MUSSER,JOHN HENRY,US, VOGEL,ROBERT LEWIS,US, KAO,WENLING,US
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A rapamycin dimer of general formula (1) (I) wherein A is -(CH2)n-, -(CH2)n-(CH=CH)-(CH2)m-, -(CH2)n-(-C 3BOND C-)-(CH2)m-, substituted alkyl, substituted alkenyl, substituted alkynyl, and substituted aromatic; n=1-10, m=1-10 and n=m or n NOTEQUAL m or a pharmaceutically acceptable salt thereof, which is by virtue of its immunosuppressive activity is useful in treating transplantation rejection host vs. graft disease, autoimmune diseases, and diseases of inflammation.