PROCESS FOR PRODUCING NEW TRICYCLIC COMPOUNDS

5-HT receptor antagonist compounds of Formula I in which: the dashed line denotes an optional bond; X and Y are independently selected from hydrogen, halogen, hydroxy, lower alkoxy, benzyloxy, lower alkyl, nitro, amino, aminocarbonyl, (lower alkyl)amino, di(lower alkyl)amino, and (lower alkanoyl)ami...

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Hauptverfasser: CLARK,ROBIN D.,US, BERGER,JACOB,US
Format: Patent
Sprache:eng
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Zusammenfassung:5-HT receptor antagonist compounds of Formula I in which: the dashed line denotes an optional bond; X and Y are independently selected from hydrogen, halogen, hydroxy, lower alkoxy, benzyloxy, lower alkyl, nitro, amino, aminocarbonyl, (lower alkyl)amino, di(lower alkyl)amino, and (lower alkanoyl)amino; Z is -O-, -S- or -N(R )-; R and R are independently selected from hydrogen and lower alkyl or are together -(CH2)n- wherein n is an integer from 2 to 4; and R is selected from in which: p is 0 or 1; q is 1, 2 or 3; and R is C1-7 alkyl; their pharmaceutically acceptable salts, individual isomers or mixtures of isomers, processes for their preparation, compositions containing them, and their use.