NEW PROCESS FOR PRODUCING AN ISOXAZOLE DERIVATIVE

NEW PROCESS FOR PRODUCING AN ISOXAZOLE DERIVATIVE

4-acetyl-amido-N-(5-methyl -3-iso-oxazolyl)-benzene -sulphonamide of formula (1) is prepd. by a novel method namely: To a suspension of N-acetyl-sulphamoyl-chloride of formula (III) in an inert low nucleophilic solvent, as a chlorinated alphatic hydrocarbon, a soln. in the same solvent of 3-amino-5-...

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Bibliographische Detailangaben
Hauptverfasser: NEMES,MIKLOS,HU, TOKAR,GEZA,HU, MANDI,ATTILA,HU, HEGEDUES,TIBOR,HU, KISS,CSABA,HU, KRASZNAI,ISTVANNE,HU, JURAK,FERENC,HU, DERCZBACH,ISTVAN,HU, PENTEK,PETER,HU, HADOBAS,KAROLYNE,HU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:4-acetyl-amido-N-(5-methyl -3-iso-oxazolyl)-benzene -sulphonamide of formula (1) is prepd. by a novel method namely: To a suspension of N-acetyl-sulphamoyl-chloride of formula (III) in an inert low nucleophilic solvent, as a chlorinated alphatic hydrocarbon, a soln. in the same solvent of 3-amino-5-methyl -iso-oxa-zole of formula (II) is added in the presence of near stoichio-metric quantities of pyridine.