PROCESS FOR PURIFYING ALKYLATED AND HYDROXYALKYLATED CYCLODEXTRINS AND FOR REDUCING THEIR UNSUBSTITUTED CYCLODEXTRIN CONTENT

Toxicity caused by contamination and nephrotoxic action of unsubstd. cyclodextrins is eliminated when their concn. is reduced by adsorption or selective complexing below toxic levels in prepns. contg. alkylated or hydroxyalkylated cyclodextrins. These prepns. are administered in large doses, parente...

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Hauptverfasser: WEISZFEILER,VIKTOR,HU, SZENTE,LAJOS,HU, UJHAZY,ANDRAS,HU, JICSINSZKY,LASZLO,HU, SZEJTLI,JOZSEF,HU
Format: Patent
Sprache:eng
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Zusammenfassung:Toxicity caused by contamination and nephrotoxic action of unsubstd. cyclodextrins is eliminated when their concn. is reduced by adsorption or selective complexing below toxic levels in prepns. contg. alkylated or hydroxyalkylated cyclodextrins. These prepns. are administered in large doses, parenterally as injections or infusions. They contain 6, 7, or 8 membered substd. (alpha,beta, gamma)cyclodextrins as solubility enhancers, carriers or preservatives