PROCESS FOR PREPARING NOVEL BENZOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AS ACTIVE SUBSTANCE

PROCESS FOR PREPARING NOVEL BENZOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AS ACTIVE SUBSTANCE

There are disclosed compounds having the formula wherein X is CR or N when n=1; or X is O, S, NR or CR when n=0; R is hydrogen or lower alkyl; Y is -CH2-, -S-, -O- or and A is Z is CH or N; R1 is halo or trifluoromethyl; R2 is hydrogen or halo; R3 is hydrogen or halo; with the proviso that when A is...

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Bibliographische Detailangaben
Hauptverfasser: BICKSLER,JAMES J,US, KEES,KENNETH L,US, PATTISON,THOMAS W,US, MUSSER,JOHN H,US, KREFT,ANTHONY F,US
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:There are disclosed compounds having the formula wherein X is CR or N when n=1; or X is O, S, NR or CR when n=0; R is hydrogen or lower alkyl; Y is -CH2-, -S-, -O- or and A is Z is CH or N; R1 is halo or trifluoromethyl; R2 is hydrogen or halo; R3 is hydrogen or halo; with the proviso that when A is naphthyl, Y is -O- and n=0, X is other than S; and their use in the treatment of inflammatory conditions and in the treatment of leukotriene-medicated naso-bronchial obstructive passageway conditions.