PROCESS FOR PREPARING OPTICALLY ACTIVE P-HYDROXY-PHENYL-GLYCINE

PROCESS FOR PREPARING OPTICALLY ACTIVE P-HYDROXY-PHENYL-GLYCINE

Racemic p-hydroxy-phenyl -glycine-alkyl-esters having 1-4 carbons in the alkyl gp. are resolved with optically active tartaric-acid in the presence of carbonyl cpds. in an aq. medium by using for 1 mole racemic glycine deriv. 0.15-0.5 mole carbonyl cpd. and 0.3-3.0 mole water. The hemi-tartarat of t...

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Hauptverfasser: HUSZAR,CSABA,HU, GARAMSZEGI,FERENC,HU, BAN,KAROLY,HU
Format: Patent
Sprache:eng
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Zusammenfassung:Racemic p-hydroxy-phenyl -glycine-alkyl-esters having 1-4 carbons in the alkyl gp. are resolved with optically active tartaric-acid in the presence of carbonyl cpds. in an aq. medium by using for 1 mole racemic glycine deriv. 0.15-0.5 mole carbonyl cpd. and 0.3-3.0 mole water. The hemi-tartarat of the optically active glycine deriv. may appear in the solvated form, from it the optically active glycine deriv. is liberated in the known way. The mothe liquor and/or washing fluids resulting from this prepn. are reused 1-30 times in the same process.