SUSTAINED RELEASE, CORE-SHELL STRUCTURE PRECIPITATED CITOKINE BIONANOCOMPOSIT, A PROCESS FOR PRODUCING THE SAME AND USE THEREOF

SUSTAINED RELEASE, CORE-SHELL STRUCTURE PRECIPITATED CITOKINE BIONANOCOMPOSIT, A PROCESS FOR PRODUCING THE SAME AND USE THEREOF

The invention relates to a sustained drug release nanocomposite, comprising a) a charge carrying core of primary protein particles reversibly precipitated in an ionic procedure from solutions containing at least one cytokine drug and b) a polyelectrolyte shell comprised of 3 to 5 alternate layers of...

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Hauptverfasser: SZEKERES MARTA DR, DEKANY IMRE DR, BALI LASZLO, PALLAI ZSOLT
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Sprache:eng
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creator SZEKERES MARTA DR
DEKANY IMRE DR
BALI LASZLO
PALLAI ZSOLT
description The invention relates to a sustained drug release nanocomposite, comprising a) a charge carrying core of primary protein particles reversibly precipitated in an ionic procedure from solutions containing at least one cytokine drug and b) a polyelectrolyte shell comprised of 3 to 5 alternate layers of two oppositely charged polyelectrolytes, the dissociation state of one of the polyelectrolytes being varied with pH of the aqueous medium while the other polyelectrolyte is fully dissociated, irrespective of the pH of the medium. There is also provided a process for producing the said nanocomposite and the use of the same for producing sustained release drug formulations.
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title SUSTAINED RELEASE, CORE-SHELL STRUCTURE PRECIPITATED CITOKINE BIONANOCOMPOSIT, A PROCESS FOR PRODUCING THE SAME AND USE THEREOF
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