PROCESS FOR THE PREPARATION OF ROSUVASTATIN VIA NEW INTERMEDIATES

PROCESS FOR THE PREPARATION OF ROSUVASTATIN VIA NEW INTERMEDIATES

The subject of the present invention is a process for the preparation of rosuvastatin by reacting a compound of formula (II), by alkalic hydrolysis to give a compound of formula (III), thereafter reacting with an organic or inorganic base to form a salt, eliminating the acetonide group and reacting...

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Hauptverfasser: DONAT ANDREA, FISCHER JANOS DR, SZEMZOE ATTILA DR, SZOEKE KATALIN, ERDELYI PETER, VUKICS KRISZTINA
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creator DONAT ANDREA
FISCHER JANOS DR
SZEMZOE ATTILA DR
SZOEKE KATALIN
ERDELYI PETER
VUKICS KRISZTINA
description The subject of the present invention is a process for the preparation of rosuvastatin by reacting a compound of formula (II), by alkalic hydrolysis to give a compound of formula (III), thereafter reacting with an organic or inorganic base to form a salt, eliminating the acetonide group and reacting with calcium-chloride in a base. A further subject of the present invention is a compound of formula (III) and its salts formed by organic or inorganic base.
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