PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS
The present invention relates to processes and intermediates for the preparation of compounds of formula (I):wherein R1 and R2 represent hydrogen or deuterium atoms; R3 represents a hydrogen atom or a -COOH, a -OH or a -OPO(OH)group; R4 represents a hydrogen atom or a fluorine atom; R5 represents a...
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| creator | TABART, Michel SCHIO, Laurent BOUABOULA, Monsif CERTAL, Victor FILOCHE-ROMME, Bruno THOMPSON, Fabienne EL-AHMAD, Youssef BROLLO, Maurice TERRIER, Corinne MCCORT, Gary HALLEY, Frank |
| description | The present invention relates to processes and intermediates for the preparation of compounds of formula (I):wherein R1 and R2 represent hydrogen or deuterium atoms; R3 represents a hydrogen atom or a -COOH, a -OH or a -OPO(OH)group; R4 represents a hydrogen atom or a fluorine atom; R5 represents a hydrogen atom or a -OH group; wherein at least one of R3 or R5 is different from a hydrogen atom; when R3 represents a-COOH, -OH or-OPO(OH)group, then R5 represents a hydrogen atom; when R5 represents a -OH group, then R3 and R4 represent hydrogen atoms; and R6 is selected from an optionally substituted phenyl, heteroaryl, cycloalkyl or heterocycloalkyl group. |
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MCCORT, Gary ; HALLEY, Frank</creator><creatorcontrib>TABART, Michel ; SCHIO, Laurent ; BOUABOULA, Monsif ; CERTAL, Victor ; FILOCHE-ROMME, Bruno ; THOMPSON, Fabienne ; EL-AHMAD, Youssef ; BROLLO, Maurice ; TERRIER, Corinne ; MCCORT, Gary ; HALLEY, Frank</creatorcontrib><description>The present invention relates to processes and intermediates for the preparation of compounds of formula (I):wherein R1 and R2 represent hydrogen or deuterium atoms; R3 represents a hydrogen atom or a -COOH, a -OH or a -OPO(OH)group; R4 represents a hydrogen atom or a fluorine atom; R5 represents a hydrogen atom or a -OH group; wherein at least one of R3 or R5 is different from a hydrogen atom; when R3 represents a-COOH, -OH or-OPO(OH)group, then R5 represents a hydrogen atom; when R5 represents a -OH group, then R3 and R4 represent hydrogen atoms; and R6 is selected from an optionally substituted phenyl, heteroaryl, cycloalkyl or heterocycloalkyl group.</description><language>eng ; hun</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220628&DB=EPODOC&CC=HU&NR=E057892T2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25555,76308</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220628&DB=EPODOC&CC=HU&NR=E057892T2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>TABART, Michel</creatorcontrib><creatorcontrib>SCHIO, Laurent</creatorcontrib><creatorcontrib>BOUABOULA, Monsif</creatorcontrib><creatorcontrib>CERTAL, Victor</creatorcontrib><creatorcontrib>FILOCHE-ROMME, Bruno</creatorcontrib><creatorcontrib>THOMPSON, Fabienne</creatorcontrib><creatorcontrib>EL-AHMAD, Youssef</creatorcontrib><creatorcontrib>BROLLO, Maurice</creatorcontrib><creatorcontrib>TERRIER, Corinne</creatorcontrib><creatorcontrib>MCCORT, Gary</creatorcontrib><creatorcontrib>HALLEY, Frank</creatorcontrib><title>PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS</title><description>The present invention relates to processes and intermediates for the preparation of compounds of formula (I):wherein R1 and R2 represent hydrogen or deuterium atoms; 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R3 represents a hydrogen atom or a -COOH, a -OH or a -OPO(OH)group; R4 represents a hydrogen atom or a fluorine atom; R5 represents a hydrogen atom or a -OH group; wherein at least one of R3 or R5 is different from a hydrogen atom; when R3 represents a-COOH, -OH or-OPO(OH)group, then R5 represents a hydrogen atom; when R5 represents a -OH group, then R3 and R4 represent hydrogen atoms; and R6 is selected from an optionally substituted phenyl, heteroaryl, cycloalkyl or heterocycloalkyl group.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF NOVEL SUBSTITUTED 6,7-DIHYDRO-5H-BENZO[7]ANNULENE COMPOUNDS |
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