SUBSTITUTED CHROMANES AND METHOD OF USE

SUBSTITUTED CHROMANES AND METHOD OF USE

wherein R1, X, Y, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, m, and R″ have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibr...

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Hauptverfasser: WANG, Xueqing, KYM, Philip R, YEUNG, Ming C, VOIGHT, Eric, BOGDAN, Andrew, SEARLE, Xenia B, LIU, Bo, ALTENBACH, Robert J, KOENIG, John R, GRESZLER, Stephen N
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Sprache:eng ; hun
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator WANG, Xueqing
KYM, Philip R
YEUNG, Ming C
VOIGHT, Eric
BOGDAN, Andrew
SEARLE, Xenia B
LIU, Bo
ALTENBACH, Robert J
KOENIG, John R
GRESZLER, Stephen N
description wherein R1, X, Y, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, m, and R″ have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title SUBSTITUTED CHROMANES AND METHOD OF USE
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