ANTI-MESOTHELIN IMMUNOCONJUGATES AND USES THEREFOR

ANTI-MESOTHELIN IMMUNOCONJUGATES AND USES THEREFOR

The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co- administered or formulated with one or more additional ant...

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Hauptverfasser: KOPITZ, Charlotte Christine, SCHUHMACHER, Joachim, HEISLER, Iring, UNTERSMANN, Kerstin, KAHNERT, Antje
Format: Patent
Sprache:eng ; hun
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator KOPITZ, Charlotte Christine
SCHUHMACHER, Joachim
HEISLER, Iring
UNTERSMANN, Kerstin
KAHNERT, Antje
description The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co- administered or formulated with one or more additional anti-cancer agents. The immunoconjugates of the invention can be used in the methods of the invention to treat and/or diagnose and/or monitor cancers, e.g. solid tumors.recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ANTI-MESOTHELIN IMMUNOCONJUGATES AND USES THEREFOR
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