2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, ITS PREPARATION, DIFFERENT SOLID FORMS AND RADIOLABELLED DERIVATIVES THEREOF

The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this inventio...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	PIERARD, Francoise, ZWICKER, Carl, ZHANG, Yuegang, MEDEK, Ales, FRAYSSE, Damien, PEGG, Simon, CHARRIER, Jean-Damien, ALEM, Naziha, SANGHVI, Tapan, WALDO, Michael, PINDER, Joanne, STUDLEY, John, SHAW, David, PANESAR, Maninder, DAVIS, Christopher, ETXEBARRIA I JARDI, Gorka
Format:	Patent
Sprache:	eng ; hun
Schlagworte:	APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	PIERARD, Francoise ZWICKER, Carl ZHANG, Yuegang MEDEK, Ales FRAYSSE, Damien PEGG, Simon CHARRIER, Jean-Damien ALEM, Naziha SANGHVI, Tapan WALDO, Michael PINDER, Joanne STUDLEY, John SHAW, David PANESAR, Maninder DAVIS, Christopher ETXEBARRIA I JARDI, Gorka
description	The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B:wherein the variables are as defined herein.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_HUE046727TT2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>HUE046727TT2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_HUE046727TT23</originalsourceid><addsrcrecordid>eNqNjMFOwzAQRHPhgIB_WO6xBCltz5t4raxwvNHarigVqipkTggqlW_kuzBSuXOaGc28uWy-O4MTBzEr43wWFRPMbvnn562y5WAWZutfasBn8bK7b5cGfyNP53ZA7eWpHlmCQaZZcrCQI7nsASNgUnjkgJGAw8g9J9EWOEWYlWZUTCyhBcvOkVJIEMWzBSc6VbheKVoWjz15TxYsKW8qs6EIaayEuOvm4u3wfio3Z71qbh2lYTTl-Lkvp-PhtXyUr_2Y6e5hte7WKXWL_2x-AKOCUCY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, ITS PREPARATION, DIFFERENT SOLID FORMS AND RADIOLABELLED DERIVATIVES THEREOF</title><source>esp@cenet</source><creator>PIERARD, Francoise ; ZWICKER, Carl ; ZHANG, Yuegang ; MEDEK, Ales ; FRAYSSE, Damien ; PEGG, Simon ; CHARRIER, Jean-Damien ; ALEM, Naziha ; SANGHVI, Tapan ; WALDO, Michael ; PINDER, Joanne ; STUDLEY, John ; SHAW, David ; PANESAR, Maninder ; DAVIS, Christopher ; ETXEBARRIA I JARDI, Gorka</creator><creatorcontrib>PIERARD, Francoise ; ZWICKER, Carl ; ZHANG, Yuegang ; MEDEK, Ales ; FRAYSSE, Damien ; PEGG, Simon ; CHARRIER, Jean-Damien ; ALEM, Naziha ; SANGHVI, Tapan ; WALDO, Michael ; PINDER, Joanne ; STUDLEY, John ; SHAW, David ; PANESAR, Maninder ; DAVIS, Christopher ; ETXEBARRIA I JARDI, Gorka</creatorcontrib><description>The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B:wherein the variables are as defined herein.</description><language>eng ; hun</language><subject>APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200330&DB=EPODOC&CC=HU&NR=E046727T2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200330&DB=EPODOC&CC=HU&NR=E046727T2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PIERARD, Francoise</creatorcontrib><creatorcontrib>ZWICKER, Carl</creatorcontrib><creatorcontrib>ZHANG, Yuegang</creatorcontrib><creatorcontrib>MEDEK, Ales</creatorcontrib><creatorcontrib>FRAYSSE, Damien</creatorcontrib><creatorcontrib>PEGG, Simon</creatorcontrib><creatorcontrib>CHARRIER, Jean-Damien</creatorcontrib><creatorcontrib>ALEM, Naziha</creatorcontrib><creatorcontrib>SANGHVI, Tapan</creatorcontrib><creatorcontrib>WALDO, Michael</creatorcontrib><creatorcontrib>PINDER, Joanne</creatorcontrib><creatorcontrib>STUDLEY, John</creatorcontrib><creatorcontrib>SHAW, David</creatorcontrib><creatorcontrib>PANESAR, Maninder</creatorcontrib><creatorcontrib>DAVIS, Christopher</creatorcontrib><creatorcontrib>ETXEBARRIA I JARDI, Gorka</creatorcontrib><title>2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, ITS PREPARATION, DIFFERENT SOLID FORMS AND RADIOLABELLED DERIVATIVES THEREOF</title><description>The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B:wherein the variables are as defined herein.</description><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjMFOwzAQRHPhgIB_WO6xBCltz5t4raxwvNHarigVqipkTggqlW_kuzBSuXOaGc28uWy-O4MTBzEr43wWFRPMbvnn562y5WAWZutfasBn8bK7b5cGfyNP53ZA7eWpHlmCQaZZcrCQI7nsASNgUnjkgJGAw8g9J9EWOEWYlWZUTCyhBcvOkVJIEMWzBSc6VbheKVoWjz15TxYsKW8qs6EIaayEuOvm4u3wfio3Z71qbh2lYTTl-Lkvp-PhtXyUr_2Y6e5hte7WKXWL_2x-AKOCUCY</recordid><startdate>20200330</startdate><enddate>20200330</enddate><creator>PIERARD, Francoise</creator><creator>ZWICKER, Carl</creator><creator>ZHANG, Yuegang</creator><creator>MEDEK, Ales</creator><creator>FRAYSSE, Damien</creator><creator>PEGG, Simon</creator><creator>CHARRIER, Jean-Damien</creator><creator>ALEM, Naziha</creator><creator>SANGHVI, Tapan</creator><creator>WALDO, Michael</creator><creator>PINDER, Joanne</creator><creator>STUDLEY, John</creator><creator>SHAW, David</creator><creator>PANESAR, Maninder</creator><creator>DAVIS, Christopher</creator><creator>ETXEBARRIA I JARDI, Gorka</creator><scope>EVB</scope></search><sort><creationdate>20200330</creationdate><title>2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, ITS PREPARATION, DIFFERENT SOLID FORMS AND RADIOLABELLED DERIVATIVES THEREOF</title><author>PIERARD, Francoise ; ZWICKER, Carl ; ZHANG, Yuegang ; MEDEK, Ales ; FRAYSSE, Damien ; PEGG, Simon ; CHARRIER, Jean-Damien ; ALEM, Naziha ; SANGHVI, Tapan ; WALDO, Michael ; PINDER, Joanne ; STUDLEY, John ; SHAW, David ; PANESAR, Maninder ; DAVIS, Christopher ; ETXEBARRIA I JARDI, Gorka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HUE046727TT23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; hun</language><creationdate>2020</creationdate><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PIERARD, Francoise</creatorcontrib><creatorcontrib>ZWICKER, Carl</creatorcontrib><creatorcontrib>ZHANG, Yuegang</creatorcontrib><creatorcontrib>MEDEK, Ales</creatorcontrib><creatorcontrib>FRAYSSE, Damien</creatorcontrib><creatorcontrib>PEGG, Simon</creatorcontrib><creatorcontrib>CHARRIER, Jean-Damien</creatorcontrib><creatorcontrib>ALEM, Naziha</creatorcontrib><creatorcontrib>SANGHVI, Tapan</creatorcontrib><creatorcontrib>WALDO, Michael</creatorcontrib><creatorcontrib>PINDER, Joanne</creatorcontrib><creatorcontrib>STUDLEY, John</creatorcontrib><creatorcontrib>SHAW, David</creatorcontrib><creatorcontrib>PANESAR, Maninder</creatorcontrib><creatorcontrib>DAVIS, Christopher</creatorcontrib><creatorcontrib>ETXEBARRIA I JARDI, Gorka</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PIERARD, Francoise</au><au>ZWICKER, Carl</au><au>ZHANG, Yuegang</au><au>MEDEK, Ales</au><au>FRAYSSE, Damien</au><au>PEGG, Simon</au><au>CHARRIER, Jean-Damien</au><au>ALEM, Naziha</au><au>SANGHVI, Tapan</au><au>WALDO, Michael</au><au>PINDER, Joanne</au><au>STUDLEY, John</au><au>SHAW, David</au><au>PANESAR, Maninder</au><au>DAVIS, Christopher</au><au>ETXEBARRIA I JARDI, Gorka</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, ITS PREPARATION, DIFFERENT SOLID FORMS AND RADIOLABELLED DERIVATIVES THEREOF</title><date>2020-03-30</date><risdate>2020</risdate><abstract>The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B:wherein the variables are as defined herein.</abstract><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	eng ; hun
recordid	cdi_epo_espacenet_HUE046727TT2
source	esp@cenet
subjects	APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	2-AMINO-6-FLUORO-N-[5-FLUORO-PYRIDIN-3-YL]PYRAZOLO[1,5-A]PYRIMIDIN-3-CARBOXAMIDE COMPOUND USEFUL AS ATR KINASE INHIBITOR, ITS PREPARATION, DIFFERENT SOLID FORMS AND RADIOLABELLED DERIVATIVES THEREOF
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T13%3A53%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=PIERARD,%20Francoise&rft.date=2020-03-30&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EHUE046727TT2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true