TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS
TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Compounds of formula I wherein: R 1 is and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase an...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; hun |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | AYRAL-KALOUSTIAN, Semiramis DEHNHARDT, Christoph M DOS SANTOS, Osvaldo CHEN, Zecheng ZASK, Arie KAPLAN, Joshua Aaron VENKATESAN, Aranapakam M DELOS SANTOS, Efren Guillermo GOPALSAMY, Ariamala CURRAN, Kevin J VERHEIJEN, Jeroen C RICHARD, David J MANSOUR, Tarek S SHI, Mengxiao |
| description | TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Compounds of formula I
wherein:
R 1 is
and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_HUE043331TT2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>HUE043331TT2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_HUE043331TT23</originalsourceid><addsrcrecordid>eNrjZDAJCfJ0jPL0c1Vw9vcN8A_1cwlWcAxWCDA0VvD29HMMdlVw9HNR8A3xD1Lw9PPwdPIEsoJ5GFjTEnOKU3mhNDeDoptriLOHbmpBfnxqcUFicmpeakm8R6irgYmxsbFhSIiRMTFqAL6JJ7w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS</title><source>esp@cenet</source><creator>AYRAL-KALOUSTIAN, Semiramis ; DEHNHARDT, Christoph M ; DOS SANTOS, Osvaldo ; CHEN, Zecheng ; ZASK, Arie ; KAPLAN, Joshua Aaron ; VENKATESAN, Aranapakam M ; DELOS SANTOS, Efren Guillermo ; GOPALSAMY, Ariamala ; CURRAN, Kevin J ; VERHEIJEN, Jeroen C ; RICHARD, David J ; MANSOUR, Tarek S ; SHI, Mengxiao</creator><creatorcontrib>AYRAL-KALOUSTIAN, Semiramis ; DEHNHARDT, Christoph M ; DOS SANTOS, Osvaldo ; CHEN, Zecheng ; ZASK, Arie ; KAPLAN, Joshua Aaron ; VENKATESAN, Aranapakam M ; DELOS SANTOS, Efren Guillermo ; GOPALSAMY, Ariamala ; CURRAN, Kevin J ; VERHEIJEN, Jeroen C ; RICHARD, David J ; MANSOUR, Tarek S ; SHI, Mengxiao</creatorcontrib><description>TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Compounds of formula I
wherein:
R 1 is
and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.</description><language>eng ; hun</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190828&DB=EPODOC&CC=HU&NR=E043331T2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190828&DB=EPODOC&CC=HU&NR=E043331T2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>AYRAL-KALOUSTIAN, Semiramis</creatorcontrib><creatorcontrib>DEHNHARDT, Christoph M</creatorcontrib><creatorcontrib>DOS SANTOS, Osvaldo</creatorcontrib><creatorcontrib>CHEN, Zecheng</creatorcontrib><creatorcontrib>ZASK, Arie</creatorcontrib><creatorcontrib>KAPLAN, Joshua Aaron</creatorcontrib><creatorcontrib>VENKATESAN, Aranapakam M</creatorcontrib><creatorcontrib>DELOS SANTOS, Efren Guillermo</creatorcontrib><creatorcontrib>GOPALSAMY, Ariamala</creatorcontrib><creatorcontrib>CURRAN, Kevin J</creatorcontrib><creatorcontrib>VERHEIJEN, Jeroen C</creatorcontrib><creatorcontrib>RICHARD, David J</creatorcontrib><creatorcontrib>MANSOUR, Tarek S</creatorcontrib><creatorcontrib>SHI, Mengxiao</creatorcontrib><title>TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS</title><description>TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Compounds of formula I
wherein:
R 1 is
and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAJCfJ0jPL0c1Vw9vcN8A_1cwlWcAxWCDA0VvD29HMMdlVw9HNR8A3xD1Lw9PPwdPIEsoJ5GFjTEnOKU3mhNDeDoptriLOHbmpBfnxqcUFicmpeakm8R6irgYmxsbFhSIiRMTFqAL6JJ7w</recordid><startdate>20190828</startdate><enddate>20190828</enddate><creator>AYRAL-KALOUSTIAN, Semiramis</creator><creator>DEHNHARDT, Christoph M</creator><creator>DOS SANTOS, Osvaldo</creator><creator>CHEN, Zecheng</creator><creator>ZASK, Arie</creator><creator>KAPLAN, Joshua Aaron</creator><creator>VENKATESAN, Aranapakam M</creator><creator>DELOS SANTOS, Efren Guillermo</creator><creator>GOPALSAMY, Ariamala</creator><creator>CURRAN, Kevin J</creator><creator>VERHEIJEN, Jeroen C</creator><creator>RICHARD, David J</creator><creator>MANSOUR, Tarek S</creator><creator>SHI, Mengxiao</creator><scope>EVB</scope></search><sort><creationdate>20190828</creationdate><title>TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS</title><author>AYRAL-KALOUSTIAN, Semiramis ; DEHNHARDT, Christoph M ; DOS SANTOS, Osvaldo ; CHEN, Zecheng ; ZASK, Arie ; KAPLAN, Joshua Aaron ; VENKATESAN, Aranapakam M ; DELOS SANTOS, Efren Guillermo ; GOPALSAMY, Ariamala ; CURRAN, Kevin J ; VERHEIJEN, Jeroen C ; RICHARD, David J ; MANSOUR, Tarek S ; SHI, Mengxiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HUE043331TT23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; hun</language><creationdate>2019</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>AYRAL-KALOUSTIAN, Semiramis</creatorcontrib><creatorcontrib>DEHNHARDT, Christoph M</creatorcontrib><creatorcontrib>DOS SANTOS, Osvaldo</creatorcontrib><creatorcontrib>CHEN, Zecheng</creatorcontrib><creatorcontrib>ZASK, Arie</creatorcontrib><creatorcontrib>KAPLAN, Joshua Aaron</creatorcontrib><creatorcontrib>VENKATESAN, Aranapakam M</creatorcontrib><creatorcontrib>DELOS SANTOS, Efren Guillermo</creatorcontrib><creatorcontrib>GOPALSAMY, Ariamala</creatorcontrib><creatorcontrib>CURRAN, Kevin J</creatorcontrib><creatorcontrib>VERHEIJEN, Jeroen C</creatorcontrib><creatorcontrib>RICHARD, David J</creatorcontrib><creatorcontrib>MANSOUR, Tarek S</creatorcontrib><creatorcontrib>SHI, Mengxiao</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>AYRAL-KALOUSTIAN, Semiramis</au><au>DEHNHARDT, Christoph M</au><au>DOS SANTOS, Osvaldo</au><au>CHEN, Zecheng</au><au>ZASK, Arie</au><au>KAPLAN, Joshua Aaron</au><au>VENKATESAN, Aranapakam M</au><au>DELOS SANTOS, Efren Guillermo</au><au>GOPALSAMY, Ariamala</au><au>CURRAN, Kevin J</au><au>VERHEIJEN, Jeroen C</au><au>RICHARD, David J</au><au>MANSOUR, Tarek S</au><au>SHI, Mengxiao</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS</title><date>2019-08-28</date><risdate>2019</risdate><abstract>TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Compounds of formula I
wherein:
R 1 is
and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; hun |
| recordid | cdi_epo_espacenet_HUE043331TT2 |
| source | esp@cenet |
| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T00%3A00%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=AYRAL-KALOUSTIAN,%20Semiramis&rft.date=2019-08-28&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EHUE043331TT2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |