6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 ("mGluR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to p...

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Hauptverfasser: CID-NUÒEZ, Jose, Maria, DECORTE, Annelies, Marie, Antonius, VAN GOOL, Michiel, Luc, Maria, ALONSO-DE DIEGO, Sergio-Alvar, MACDONALD, Gregor, James, ANDRES-GIL, Jose, Ignacio, TRABANCO-SUAREZ, Andres, Avelino, MEGENS, Antonius, Adrianus, Hendrikus, Petrus, DELGADO-GONZALEZ, Oscar, GARCIA-MOLINA, Aranzazu
Format: Patent
Sprache:eng ; hun
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator CID-NUÒEZ, Jose, Maria
DECORTE, Annelies, Marie, Antonius
VAN GOOL, Michiel, Luc, Maria
ALONSO-DE DIEGO, Sergio-Alvar
MACDONALD, Gregor, James
ANDRES-GIL, Jose, Ignacio
TRABANCO-SUAREZ, Andres, Avelino
MEGENS, Antonius, Adrianus, Hendrikus, Petrus
DELGADO-GONZALEZ, Oscar
GARCIA-MOLINA, Aranzazu
description The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 ("mGluR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title 6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
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