SLOW RELEASE PHARMACEUTICAL COMPOSITION MADE OF MICROPARTICLES

Pharmaceutical composition made of microparticles for the slow release of an active substance at least during a period covering the 6 th month after injection of said composition, said composition comprising a group of microparticles made of a copolymer of the PLGA type which incorporate an active s...

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Hauptverfasser: DUCREY, Bertrand, HEIMGARTNER, Frederic, PORCHET, Herve, LUNDSTROM, Eija, BARDET, Marie-Anne, CURDY, Catherine, GARROUSTE, Patrick
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creator DUCREY, Bertrand
HEIMGARTNER, Frederic
PORCHET, Herve
LUNDSTROM, Eija
BARDET, Marie-Anne
CURDY, Catherine
GARROUSTE, Patrick
description Pharmaceutical composition made of microparticles for the slow release of an active substance at least during a period covering the 6 th month after injection of said composition, said composition comprising a group of microparticles made of a copolymer of the PLGA type which incorporate an active substance in the form of a water insoluble peptide salt; said copolymer furthermore comprising at least 75 % of lactic acid and an inherent viscosity between 0.1 and 0.9 dl/g, as measured in chloroform at 25 °C and at a polymer concentration of 0.5 g/dL; said microparticles furthermore having a size distribution defined as follows : - D (v,0.1) is between 10 and 30 micrometers, - D (v,0.5) is between 30 and 70 micrometers, - D(v,0.9) is between 50 and 110 micrometers.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title SLOW RELEASE PHARMACEUTICAL COMPOSITION MADE OF MICROPARTICLES
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