THIENOPYRIDONE DERIVATIVES USEFUL AS ACTIVATORS OF AMPK

THIENOPYRIDONE DERIVATIVES USEFUL AS ACTIVATORS OF AMPK

The invention relates to compounds that are direct activators of AMPK (AMP-activated protein kinase) and their use in the treatment of disorders regulated by activation of AMPK. For instance, compounds according to the invention are useful for the treatment of diabetes, metabolic syndrome, obesity,...

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Hauptverfasser: HALLAKOU-BOZEC, Sophie, BOLZE, Sebastien, CHARON, Christine, LEPIFRE, Franck, CRAVO, Daniel, FAVERIEL, Laurent, DURAND, Jean-Denis
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Sprache:eng ; hun
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator HALLAKOU-BOZEC, Sophie
BOLZE, Sebastien
CHARON, Christine
LEPIFRE, Franck
CRAVO, Daniel
FAVERIEL, Laurent
DURAND, Jean-Denis
description The invention relates to compounds that are direct activators of AMPK (AMP-activated protein kinase) and their use in the treatment of disorders regulated by activation of AMPK. For instance, compounds according to the invention are useful for the treatment of diabetes, metabolic syndrome, obesity, liver disease, hepatic steatosis, non alcoholic fatty liver disease (NAFLD), non alcoholic steato-hepatitis (NASH), liver fibrosis, dyslipidemia, hypertriglyceridemia, hypercholesterolemia, inflammation, cancer, cardiovascular diseases, atherosclerosis, high blood pressure, retinopathies or neuropathies.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title THIENOPYRIDONE DERIVATIVES USEFUL AS ACTIVATORS OF AMPK
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