VEGF antagonist formulations suitable for intravitreal administration

VEGF antagonist formulations suitable for intravitreal administration

Ophthalmic formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided suitable for intravitreal administration to the eye. The ophthalmic formulations include a stable liquid formulation and a lyophilizable formulation. Preferably, the protein antagon...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: FURFINE, Eric, Dix, Daniel, Frye, Kelly, Graham, Kenneth
Format: Patent
Sprache:eng ; hun
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Ophthalmic formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided suitable for intravitreal administration to the eye. The ophthalmic formulations include a stable liquid formulation and a lyophilizable formulation. Preferably, the protein antagonist has the amino acid sequence shown in SEQ ID NO:4. A pre-filled syringe is provided which is suitable for intravitreal administration comprising a stable ophthalmic formulation of a vascular endothelial growth factor (VEGF) antagonist.