CYCLOHEXYL(ALKYL)-PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an -S(O)z(C1-C4)alkyl group, an -NHSO2(C1-C4)alkyl group, an -SO2NH(C1-C4)alkyl group, an -NHSO2phenyl-(C1-C4)alkyl group or an -NHSO2phenyl gr...
Gespeichert in:
Hauptverfasser: | , , , , , |
---|---|
Format: | Patent |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | |
container_start_page | |
container_title | |
container_volume | |
creator | OLIVA, AMBROGIO VIVIANI, NUNZIA CROCI, TIZIANO COURTEMANCHE, GILLES CECCHI, ROBERTO BOVY, PHILIPPE R |
description | The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an -S(O)z(C1-C4)alkyl group, an -NHSO2(C1-C4)alkyl group, an -SO2NH(C1-C4)alkyl group, an -NHSO2phenyl-(C1-C4)alkyl group or an -NHSO2phenyl group, said phenyl possibly being substituted with a halogen atom, with a (C1-C4)alkyl group or with a (C1-C4)alkoxy group; R1 represents a hydrogen atom or a (C1-C4)alkyl group, a -CO(C1-C4)alkyl group, a phenyl-(C1-C4)alkyl group or a -COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1-C4)alkoxy group; R2 is a hydrogen atom or an -SO2(C1-C4)alkyl group, an -SO2phenyl-(C1-C4)alkyl group or an -SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1-C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogen atom, a (C1-C6)alkyl group, a (C1-C4)alkoxy group, a -COO(C1-C4)alkyl group, a -CO(C1-C4)alkyl group, an -NHSO2(C1-C4)alkyl group, an -NHSO2phenyl-(C1-C4)alkyl groups, -NO2, -CN, -CONR4R5, -COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; R4 and R5 represent, independently, a hydrogen atom, a phenyl, a (C1-C4)alkyl group or a phenyl-(C1-C4)alkyl group or R4 and R5 with the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process. |
format | Patent |
fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_HU229583B1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>HU229583B1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_HU229583B13</originalsourceid><addsrcrecordid>eNqFyrEKwjAQgOEuDqI-gxkV7GCLoOOZniaY3IUkBTuVonESLdT3RwV3p58fvnF2lY00rPDcmAWYU2OWufPsgNiA1YRhJZxHBx6iZhIWo-JKAFXCKfAWJNZRSzBCsnUc9FeFz1AETZqOIoDFaTa6dfchzX6dZPMDRqny1D_bNPTdJT3Sq1V1Uew223K_Lv-LN9dNNGM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>CYCLOHEXYL(ALKYL)-PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME</title><source>esp@cenet</source><creator>OLIVA, AMBROGIO ; VIVIANI, NUNZIA ; CROCI, TIZIANO ; COURTEMANCHE, GILLES ; CECCHI, ROBERTO ; BOVY, PHILIPPE R</creator><creatorcontrib>OLIVA, AMBROGIO ; VIVIANI, NUNZIA ; CROCI, TIZIANO ; COURTEMANCHE, GILLES ; CECCHI, ROBERTO ; BOVY, PHILIPPE R</creatorcontrib><description>The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an -S(O)z(C1-C4)alkyl group, an -NHSO2(C1-C4)alkyl group, an -SO2NH(C1-C4)alkyl group, an -NHSO2phenyl-(C1-C4)alkyl group or an -NHSO2phenyl group, said phenyl possibly being substituted with a halogen atom, with a (C1-C4)alkyl group or with a (C1-C4)alkoxy group; R1 represents a hydrogen atom or a (C1-C4)alkyl group, a -CO(C1-C4)alkyl group, a phenyl-(C1-C4)alkyl group or a -COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1-C4)alkoxy group; R2 is a hydrogen atom or an -SO2(C1-C4)alkyl group, an -SO2phenyl-(C1-C4)alkyl group or an -SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1-C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogen atom, a (C1-C6)alkyl group, a (C1-C4)alkoxy group, a -COO(C1-C4)alkyl group, a -CO(C1-C4)alkyl group, an -NHSO2(C1-C4)alkyl group, an -NHSO2phenyl-(C1-C4)alkyl groups, -NO2, -CN, -CONR4R5, -COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; R4 and R5 represent, independently, a hydrogen atom, a phenyl, a (C1-C4)alkyl group or a phenyl-(C1-C4)alkyl group or R4 and R5 with the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2014</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140228&DB=EPODOC&CC=HU&NR=229583B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20140228&DB=EPODOC&CC=HU&NR=229583B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OLIVA, AMBROGIO</creatorcontrib><creatorcontrib>VIVIANI, NUNZIA</creatorcontrib><creatorcontrib>CROCI, TIZIANO</creatorcontrib><creatorcontrib>COURTEMANCHE, GILLES</creatorcontrib><creatorcontrib>CECCHI, ROBERTO</creatorcontrib><creatorcontrib>BOVY, PHILIPPE R</creatorcontrib><title>CYCLOHEXYL(ALKYL)-PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME</title><description>The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an -S(O)z(C1-C4)alkyl group, an -NHSO2(C1-C4)alkyl group, an -SO2NH(C1-C4)alkyl group, an -NHSO2phenyl-(C1-C4)alkyl group or an -NHSO2phenyl group, said phenyl possibly being substituted with a halogen atom, with a (C1-C4)alkyl group or with a (C1-C4)alkoxy group; R1 represents a hydrogen atom or a (C1-C4)alkyl group, a -CO(C1-C4)alkyl group, a phenyl-(C1-C4)alkyl group or a -COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1-C4)alkoxy group; R2 is a hydrogen atom or an -SO2(C1-C4)alkyl group, an -SO2phenyl-(C1-C4)alkyl group or an -SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1-C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogen atom, a (C1-C6)alkyl group, a (C1-C4)alkoxy group, a -COO(C1-C4)alkyl group, a -CO(C1-C4)alkyl group, an -NHSO2(C1-C4)alkyl group, an -NHSO2phenyl-(C1-C4)alkyl groups, -NO2, -CN, -CONR4R5, -COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; R4 and R5 represent, independently, a hydrogen atom, a phenyl, a (C1-C4)alkyl group or a phenyl-(C1-C4)alkyl group or R4 and R5 with the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2014</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFyrEKwjAQgOEuDqI-gxkV7GCLoOOZniaY3IUkBTuVonESLdT3RwV3p58fvnF2lY00rPDcmAWYU2OWufPsgNiA1YRhJZxHBx6iZhIWo-JKAFXCKfAWJNZRSzBCsnUc9FeFz1AETZqOIoDFaTa6dfchzX6dZPMDRqny1D_bNPTdJT3Sq1V1Uew223K_Lv-LN9dNNGM</recordid><startdate>20140228</startdate><enddate>20140228</enddate><creator>OLIVA, AMBROGIO</creator><creator>VIVIANI, NUNZIA</creator><creator>CROCI, TIZIANO</creator><creator>COURTEMANCHE, GILLES</creator><creator>CECCHI, ROBERTO</creator><creator>BOVY, PHILIPPE R</creator><scope>EVB</scope></search><sort><creationdate>20140228</creationdate><title>CYCLOHEXYL(ALKYL)-PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME</title><author>OLIVA, AMBROGIO ; VIVIANI, NUNZIA ; CROCI, TIZIANO ; COURTEMANCHE, GILLES ; CECCHI, ROBERTO ; BOVY, PHILIPPE R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HU229583B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2014</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>OLIVA, AMBROGIO</creatorcontrib><creatorcontrib>VIVIANI, NUNZIA</creatorcontrib><creatorcontrib>CROCI, TIZIANO</creatorcontrib><creatorcontrib>COURTEMANCHE, GILLES</creatorcontrib><creatorcontrib>CECCHI, ROBERTO</creatorcontrib><creatorcontrib>BOVY, PHILIPPE R</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OLIVA, AMBROGIO</au><au>VIVIANI, NUNZIA</au><au>CROCI, TIZIANO</au><au>COURTEMANCHE, GILLES</au><au>CECCHI, ROBERTO</au><au>BOVY, PHILIPPE R</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CYCLOHEXYL(ALKYL)-PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME</title><date>2014-02-28</date><risdate>2014</risdate><abstract>The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an -S(O)z(C1-C4)alkyl group, an -NHSO2(C1-C4)alkyl group, an -SO2NH(C1-C4)alkyl group, an -NHSO2phenyl-(C1-C4)alkyl group or an -NHSO2phenyl group, said phenyl possibly being substituted with a halogen atom, with a (C1-C4)alkyl group or with a (C1-C4)alkoxy group; R1 represents a hydrogen atom or a (C1-C4)alkyl group, a -CO(C1-C4)alkyl group, a phenyl-(C1-C4)alkyl group or a -COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1-C4)alkoxy group; R2 is a hydrogen atom or an -SO2(C1-C4)alkyl group, an -SO2phenyl-(C1-C4)alkyl group or an -SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1-C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogen atom, a (C1-C6)alkyl group, a (C1-C4)alkoxy group, a -COO(C1-C4)alkyl group, a -CO(C1-C4)alkyl group, an -NHSO2(C1-C4)alkyl group, an -NHSO2phenyl-(C1-C4)alkyl groups, -NO2, -CN, -CONR4R5, -COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; R4 and R5 represent, independently, a hydrogen atom, a phenyl, a (C1-C4)alkyl group or a phenyl-(C1-C4)alkyl group or R4 and R5 with the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.</abstract><oa>free_for_read</oa></addata></record> |
fulltext | fulltext_linktorsrc |
identifier | |
ispartof | |
issn | |
language | eng |
recordid | cdi_epo_espacenet_HU229583B1 |
source | esp@cenet |
subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | CYCLOHEXYL(ALKYL)-PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T04%3A55%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=OLIVA,%20AMBROGIO&rft.date=2014-02-28&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EHU229583B1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |