CYCLOHEXYL(ALKYL)-PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an -S(O)z(C1-C4)alkyl group, an -NHSO2(C1-C4)alkyl group, an -SO2NH(C1-C4)alkyl group, an -NHSO2phenyl-(C1-C4)alkyl group or an -NHSO2phenyl gr...

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Hauptverfasser: OLIVA, AMBROGIO, VIVIANI, NUNZIA, CROCI, TIZIANO, COURTEMANCHE, GILLES, CECCHI, ROBERTO, BOVY, PHILIPPE R
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creator OLIVA, AMBROGIO
VIVIANI, NUNZIA
CROCI, TIZIANO
COURTEMANCHE, GILLES
CECCHI, ROBERTO
BOVY, PHILIPPE R
description The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an -S(O)z(C1-C4)alkyl group, an -NHSO2(C1-C4)alkyl group, an -SO2NH(C1-C4)alkyl group, an -NHSO2phenyl-(C1-C4)alkyl group or an -NHSO2phenyl group, said phenyl possibly being substituted with a halogen atom, with a (C1-C4)alkyl group or with a (C1-C4)alkoxy group; R1 represents a hydrogen atom or a (C1-C4)alkyl group, a -CO(C1-C4)alkyl group, a phenyl-(C1-C4)alkyl group or a -COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1-C4)alkoxy group; R2 is a hydrogen atom or an -SO2(C1-C4)alkyl group, an -SO2phenyl-(C1-C4)alkyl group or an -SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1-C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogen atom, a (C1-C6)alkyl group, a (C1-C4)alkoxy group, a -COO(C1-C4)alkyl group, a -CO(C1-C4)alkyl group, an -NHSO2(C1-C4)alkyl group, an -NHSO2phenyl-(C1-C4)alkyl groups, -NO2, -CN, -CONR4R5, -COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; R4 and R5 represent, independently, a hydrogen atom, a phenyl, a (C1-C4)alkyl group or a phenyl-(C1-C4)alkyl group or R4 and R5 with the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.
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R1 represents a hydrogen atom or a (C1-C4)alkyl group, a -CO(C1-C4)alkyl group, a phenyl-(C1-C4)alkyl group or a -COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1-C4)alkoxy group; R2 is a hydrogen atom or an -SO2(C1-C4)alkyl group, an -SO2phenyl-(C1-C4)alkyl group or an -SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1-C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogen atom, a (C1-C6)alkyl group, a (C1-C4)alkoxy group, a -COO(C1-C4)alkyl group, a -CO(C1-C4)alkyl group, an -NHSO2(C1-C4)alkyl group, an -NHSO2phenyl-(C1-C4)alkyl groups, -NO2, -CN, -CONR4R5, -COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; R4 and R5 represent, independently, a hydrogen atom, a phenyl, a (C1-C4)alkyl group or a phenyl-(C1-C4)alkyl group or R4 and R5 with the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.</abstract><oa>free_for_read</oa></addata></record>
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title CYCLOHEXYL(ALKYL)-PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
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