PROCESS FOR PRODUCING A-NOR-SECO-STEROIDE COMPOUNDS, SECO-INDOXYLIDENECARBOXILICACID DERIVETIVES AS INTERMEDIATES THEREOF

PROCESS FOR PRODUCING A-NOR-SECO-STEROIDE COMPOUNDS, SECO-INDOXYLIDENECARBOXILICACID DERIVETIVES AS INTERMEDIATES THEREOF

The invention relates to a new process for the synthesis of 17beta-hydroxy-17alpha-methyl-1,3-seco-2-nor-5alpha-androstane-3-acid derivatives of formula (I)wherein the meaning of Z is carboxyl or formyl group andto the new secoindoxylidene carboxylic acid derivatives of formula (II)wherein R1 and R2...

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Bibliographische Detailangaben
Hauptverfasser: SANTA CSABA, MAHO SANDOR, SZILAGYI GABRIELLA, BALOGH GABOR, BRLIK JANOS, BAKCSI ERIKA, SZELES JANOS, TUBA ZOLTAN DR, TRISCHLER FERENC DR
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a new process for the synthesis of 17beta-hydroxy-17alpha-methyl-1,3-seco-2-nor-5alpha-androstane-3-acid derivatives of formula (I)wherein the meaning of Z is carboxyl or formyl group andto the new secoindoxylidene carboxylic acid derivatives of formula (II)wherein R1 and R2 independently are C1-C4 alkyl or alkoxy group, hydrogen or halogen atom-which are intermediates for preparing the compounds of formula (I).The 17beta-hydroxy-17alpha-methyl-1,3-seco-2-nor-5alpha-androstane-3-acid derivatives of formula (I) are intermediates in the synthesis of oxandrolon (17beta-hydroxy-17alpha-methyl-2-oxa-5alpha-androstane-3-one), which is used as anabolic in therapy.