POLYPEPTIDE ANALOGS OF PARATHYROID HORMONE (PTH) PROCESSES FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF OSTEOPOROSIS CONTAINING THEREOF
A találmány a paratiroid hormonnal (PTH) rokon új polipeptidekre,továbbá gyógyszerészetileg megfelelő sóikra vonatkozik. A találmányfoglalkozik a nevezett polipeptideket tartalmazógyógyszerkészítményekkel, amelyek emlősökben hasznosak a csontritkulásmegelőzésére és kezelésére. A találmányban eljárás...
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| creator | BACH, CHINH T VICKERY, BRIAN H KRSTENANSKY, JOHN L NESTOR, JOHN J HO, TERESA L |
| description | A találmány a paratiroid hormonnal (PTH) rokon új polipeptidekre,továbbá gyógyszerészetileg megfelelő sóikra vonatkozik. A találmányfoglalkozik a nevezett polipeptideket tartalmazógyógyszerkészítményekkel, amelyek emlősökben hasznosak a csontritkulásmegelőzésére és kezelésére. A találmányban eljárásokat írnak le anevezett polipeptidek szilárd fázisú és rekombináns módszerekkeltörténő előállítására. ŕ
Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic alpha -helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa)2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided. |
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Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic alpha -helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa)2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.</description><edition>7</edition><language>eng ; hun</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2000</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20000428&DB=EPODOC&CC=HU&NR=217843B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20000428&DB=EPODOC&CC=HU&NR=217843B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BACH, CHINH T</creatorcontrib><creatorcontrib>VICKERY, BRIAN H</creatorcontrib><creatorcontrib>KRSTENANSKY, JOHN L</creatorcontrib><creatorcontrib>NESTOR, JOHN J</creatorcontrib><creatorcontrib>HO, TERESA L</creatorcontrib><title>POLYPEPTIDE ANALOGS OF PARATHYROID HORMONE (PTH) PROCESSES FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF OSTEOPOROSIS CONTAINING THEREOF</title><description>A találmány a paratiroid hormonnal (PTH) rokon új polipeptidekre,továbbá gyógyszerészetileg megfelelő sóikra vonatkozik. A találmányfoglalkozik a nevezett polipeptideket tartalmazógyógyszerkészítményekkel, amelyek emlősökben hasznosak a csontritkulásmegelőzésére és kezelésére. A találmányban eljárásokat írnak le anevezett polipeptidek szilárd fázisú és rekombináns módszerekkeltörténő előállítására. ŕ
Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic alpha -helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa)2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2000</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjbFqw0AQRNWkCE5-IWzpFCliB5x2fVrpDnS3y96qcGVEOFfGEShflC-NRNS7GgbevHmsfoW7k5BYqAkwYcdtBm5AUNH8STnU4FkjJ4KtmH8FUXaUM2VoWJdW9y6kFsxTnA01iEeN6Ki34LADx1E4Bwuc_iczCKaEFinZ8sXZiIV1pvKMJ8OQVqMSN0_Vw2W4TuV5zU310pA5_1bG73OZxuGr3MrP2fe798Pnx_64vwv8AdEtRQk</recordid><startdate>20000428</startdate><enddate>20000428</enddate><creator>BACH, CHINH T</creator><creator>VICKERY, BRIAN H</creator><creator>KRSTENANSKY, JOHN L</creator><creator>NESTOR, JOHN J</creator><creator>HO, TERESA L</creator><scope>EVB</scope></search><sort><creationdate>20000428</creationdate><title>POLYPEPTIDE ANALOGS OF PARATHYROID HORMONE (PTH) PROCESSES FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF OSTEOPOROSIS CONTAINING THEREOF</title><author>BACH, CHINH T ; VICKERY, BRIAN H ; KRSTENANSKY, JOHN L ; NESTOR, JOHN J ; HO, TERESA L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HU217843B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; hun</language><creationdate>2000</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>BACH, CHINH T</creatorcontrib><creatorcontrib>VICKERY, BRIAN H</creatorcontrib><creatorcontrib>KRSTENANSKY, JOHN L</creatorcontrib><creatorcontrib>NESTOR, JOHN J</creatorcontrib><creatorcontrib>HO, TERESA L</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BACH, CHINH T</au><au>VICKERY, BRIAN H</au><au>KRSTENANSKY, JOHN L</au><au>NESTOR, JOHN J</au><au>HO, TERESA L</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>POLYPEPTIDE ANALOGS OF PARATHYROID HORMONE (PTH) PROCESSES FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF OSTEOPOROSIS CONTAINING THEREOF</title><date>2000-04-28</date><risdate>2000</risdate><abstract>A találmány a paratiroid hormonnal (PTH) rokon új polipeptidekre,továbbá gyógyszerészetileg megfelelő sóikra vonatkozik. A találmányfoglalkozik a nevezett polipeptideket tartalmazógyógyszerkészítményekkel, amelyek emlősökben hasznosak a csontritkulásmegelőzésére és kezelésére. A találmányban eljárásokat írnak le anevezett polipeptidek szilárd fázisú és rekombináns módszerekkeltörténő előállítására. ŕ
Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic alpha -helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa)2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of ostoporosis in mammals. Processes for the production of the polypeptides via solid phase and recombinant methods are provided.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | POLYPEPTIDE ANALOGS OF PARATHYROID HORMONE (PTH) PROCESSES FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF OSTEOPOROSIS CONTAINING THEREOF |
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