PROCESS FOR PRODUCING DEAZAPURINE NUCLEOSIDE DERIVATIVES AND ANTIVIRAL COMPOSITIONS COMPRISING SAID COMPOUNDS

Novel deazapurine nucleosides of the formula I in which X denotes nitrogen or a methine group, W denotes nitrogen or the group R , R , R and R can be the same or different, and denote hydrogen, halogen, a lower alkyl, hydroxyl, mercapto, lower alkylthio, lower alkyloxy, aralkyl, aralkyloxy, aryloxy...

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Hauptverfasser: SEELA,FRANZ,DE, MUTH,HEINZ-PETER,DE
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MUTH,HEINZ-PETER,DE
description Novel deazapurine nucleosides of the formula I in which X denotes nitrogen or a methine group, W denotes nitrogen or the group R , R , R and R can be the same or different, and denote hydrogen, halogen, a lower alkyl, hydroxyl, mercapto, lower alkylthio, lower alkyloxy, aralkyl, aralkyloxy, aryloxy or an optionally mono- or disubstituted amino group, R denotes hydrogen or a hydroxyl group, R and R each denote hydrogen or one of the two radicals R and R denotes halogen, a cyano, azido or an optionally mono- or disubstituted amino group, where one of the radicals R and R can also represent a hydroxyl group if X denotes a methine group, and R and R together can additionally represent a further bond between C-2' and C-3' and Y represents hydrogen, a monophosphate, diphosphate or triphosphate group, and possible tautomers and salts and nucleic acids which contain one or more compounds of the formula I as building block. The compounds according to the invention exhibit antiviral properties and can further be used in DNA sequencing, where they lead to chain termination and/or prevent band compression.
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The compounds according to the invention exhibit antiviral properties and can further be used in DNA sequencing, where they lead to chain termination and/or prevent band compression.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record>
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
SUGARS
VINEGAR
WINE
title PROCESS FOR PRODUCING DEAZAPURINE NUCLEOSIDE DERIVATIVES AND ANTIVIRAL COMPOSITIONS COMPRISING SAID COMPOUNDS
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