PROCESS FOR PRODUCING DEAZAPURINE NUCLEOSIDE DERIVATIVES AND ANTIVIRAL COMPOSITIONS COMPRISING SAID COMPOUNDS
Novel deazapurine nucleosides of the formula I in which X denotes nitrogen or a methine group, W denotes nitrogen or the group R , R , R and R can be the same or different, and denote hydrogen, halogen, a lower alkyl, hydroxyl, mercapto, lower alkylthio, lower alkyloxy, aralkyl, aralkyloxy, aryloxy...
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creator | SEELA,FRANZ,DE MUTH,HEINZ-PETER,DE |
description | Novel deazapurine nucleosides of the formula I in which X denotes nitrogen or a methine group, W denotes nitrogen or the group R , R , R and R can be the same or different, and denote hydrogen, halogen, a lower alkyl, hydroxyl, mercapto, lower alkylthio, lower alkyloxy, aralkyl, aralkyloxy, aryloxy or an optionally mono- or disubstituted amino group, R denotes hydrogen or a hydroxyl group, R and R each denote hydrogen or one of the two radicals R and R denotes halogen, a cyano, azido or an optionally mono- or disubstituted amino group, where one of the radicals R and R can also represent a hydroxyl group if X denotes a methine group, and R and R together can additionally represent a further bond between C-2' and C-3' and Y represents hydrogen, a monophosphate, diphosphate or triphosphate group, and possible tautomers and salts and nucleic acids which contain one or more compounds of the formula I as building block. The compounds according to the invention exhibit antiviral properties and can further be used in DNA sequencing, where they lead to chain termination and/or prevent band compression. |
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The compounds according to the invention exhibit antiviral properties and can further be used in DNA sequencing, where they lead to chain termination and/or prevent band compression.</description><edition>4</edition><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; DERIVATIVES THEREOF ; ENZYMOLOGY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; SUGARS ; VINEGAR ; WINE</subject><creationdate>1990</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900328&DB=EPODOC&CC=HU&NR=199871B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900328&DB=EPODOC&CC=HU&NR=199871B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SEELA,FRANZ,DE</creatorcontrib><creatorcontrib>MUTH,HEINZ-PETER,DE</creatorcontrib><title>PROCESS FOR PRODUCING DEAZAPURINE NUCLEOSIDE DERIVATIVES AND ANTIVIRAL COMPOSITIONS COMPRISING SAID COMPOUNDS</title><description>Novel deazapurine nucleosides of the formula I in which X denotes nitrogen or a methine group, W denotes nitrogen or the group R , R , R and R can be the same or different, and denote hydrogen, halogen, a lower alkyl, hydroxyl, mercapto, lower alkylthio, lower alkyloxy, aralkyl, aralkyloxy, aryloxy or an optionally mono- or disubstituted amino group, R denotes hydrogen or a hydroxyl group, R and R each denote hydrogen or one of the two radicals R and R denotes halogen, a cyano, azido or an optionally mono- or disubstituted amino group, where one of the radicals R and R can also represent a hydroxyl group if X denotes a methine group, and R and R together can additionally represent a further bond between C-2' and C-3' and Y represents hydrogen, a monophosphate, diphosphate or triphosphate group, and possible tautomers and salts and nucleic acids which contain one or more compounds of the formula I as building block. The compounds according to the invention exhibit antiviral properties and can further be used in DNA sequencing, where they lead to chain termination and/or prevent band compression.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1990</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFTLsKwjAUzeIg6i9IfsChOGjHNLm1F2oS7k06uJQicfJRqP-P8bE7HM6TMxc3T04Ds6wdyaxN1GgP0oA6KR8JLUgbdQuO0UCOCTsVsAOWypqMrJFUK7U7-rwJ6Cx_DCG_j1ih-ZbRGl6K2WW4Tmn144VY1xB0s0njo0_TOJzTPT37JhZlud8V1fbv4AVe_DbA</recordid><startdate>19900328</startdate><enddate>19900328</enddate><creator>SEELA,FRANZ,DE</creator><creator>MUTH,HEINZ-PETER,DE</creator><scope>EVB</scope></search><sort><creationdate>19900328</creationdate><title>PROCESS FOR PRODUCING DEAZAPURINE NUCLEOSIDE DERIVATIVES AND ANTIVIRAL COMPOSITIONS COMPRISING SAID COMPOUNDS</title><author>SEELA,FRANZ,DE ; MUTH,HEINZ-PETER,DE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HU199871B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1990</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SEELA,FRANZ,DE</creatorcontrib><creatorcontrib>MUTH,HEINZ-PETER,DE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SEELA,FRANZ,DE</au><au>MUTH,HEINZ-PETER,DE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PRODUCING DEAZAPURINE NUCLEOSIDE DERIVATIVES AND ANTIVIRAL COMPOSITIONS COMPRISING SAID COMPOUNDS</title><date>1990-03-28</date><risdate>1990</risdate><abstract>Novel deazapurine nucleosides of the formula I in which X denotes nitrogen or a methine group, W denotes nitrogen or the group R , R , R and R can be the same or different, and denote hydrogen, halogen, a lower alkyl, hydroxyl, mercapto, lower alkylthio, lower alkyloxy, aralkyl, aralkyloxy, aryloxy or an optionally mono- or disubstituted amino group, R denotes hydrogen or a hydroxyl group, R and R each denote hydrogen or one of the two radicals R and R denotes halogen, a cyano, azido or an optionally mono- or disubstituted amino group, where one of the radicals R and R can also represent a hydroxyl group if X denotes a methine group, and R and R together can additionally represent a further bond between C-2' and C-3' and Y represents hydrogen, a monophosphate, diphosphate or triphosphate group, and possible tautomers and salts and nucleic acids which contain one or more compounds of the formula I as building block. The compounds according to the invention exhibit antiviral properties and can further be used in DNA sequencing, where they lead to chain termination and/or prevent band compression.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE |
title | PROCESS FOR PRODUCING DEAZAPURINE NUCLEOSIDE DERIVATIVES AND ANTIVIRAL COMPOSITIONS COMPRISING SAID COMPOUNDS |
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