PROCESS FOR PRODUCING DOXYCYCLINE
PCT No. PCT/HU88/00063 Sec. 371 Date May 5, 1989 Sec. 102(e) Date May 5, 1989 PCT Filed Sep. 16, 1988 PCT Pub. No. WO89/02429 PCT Pub. Date Mar. 23, 1989.The invention relates to a process for the preparation of tetracycline derivatives of the formula I. and acid addition salts thereof -wherein R st...
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| creator | SIMONIDESZ,VILMOS,HU NAGY,LAJOS,HU LUGOSI,MARTA,HU LUGOSI,GYOERGY,HU SIMANDI,LASZLO,HU SZALAY,ERZSEBET,HU SANTA,JOZSEFNE,HU NAD,ZSUZSANNA,HU BESENYEI,GABOR,HU GYOERY,PETER,HU JELINEK,ISTVAN,HU KALLAY U.,TAMAS,HU |
| description | PCT No. PCT/HU88/00063 Sec. 371 Date May 5, 1989 Sec. 102(e) Date May 5, 1989 PCT Filed Sep. 16, 1988 PCT Pub. No. WO89/02429 PCT Pub. Date Mar. 23, 1989.The invention relates to a process for the preparation of tetracycline derivatives of the formula I. and acid addition salts thereof -wherein R stands for -CH3 or =CH2-by dehalogenating and hydrogenating chloromethacycline or acid addition salt thereof of the formula II. or by hydrating methacycline or acid addition salts thereof of the formula III. by treatment with hydrogen gas in the presence of a noble metal alloy catalyst on carrier and organic solvent which comprises performing, hydrogenating under pressure of 0.1-1.0 MPa with an alloy catalyst consisting of the alloy palladium or platinum and selenium and/or tellurium used at a ratio of 1:0.01-0.5 related to the amount of the starting tetracycline and carrying out, if desired dehalogenation and hydrogenation in one step. |
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No. WO89/02429 PCT Pub. Date Mar. 23, 1989.The invention relates to a process for the preparation of tetracycline derivatives of the formula I. and acid addition salts thereof -wherein R stands for -CH3 or =CH2-by dehalogenating and hydrogenating chloromethacycline or acid addition salt thereof of the formula II. or by hydrating methacycline or acid addition salts thereof of the formula III. by treatment with hydrogen gas in the presence of a noble metal alloy catalyst on carrier and organic solvent which comprises performing, hydrogenating under pressure of 0.1-1.0 MPa with an alloy catalyst consisting of the alloy palladium or platinum and selenium and/or tellurium used at a ratio of 1:0.01-0.5 related to the amount of the starting tetracycline and carrying out, if desired dehalogenation and hydrogenation in one step.</description><edition>4</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; THEIR RELEVANT APPARATUS ; TRANSPORTING</subject><creationdate>1989</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890828&DB=EPODOC&CC=HU&NR=198173B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890828&DB=EPODOC&CC=HU&NR=198173B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SIMONIDESZ,VILMOS,HU</creatorcontrib><creatorcontrib>NAGY,LAJOS,HU</creatorcontrib><creatorcontrib>LUGOSI,MARTA,HU</creatorcontrib><creatorcontrib>LUGOSI,GYOERGY,HU</creatorcontrib><creatorcontrib>SIMANDI,LASZLO,HU</creatorcontrib><creatorcontrib>SZALAY,ERZSEBET,HU</creatorcontrib><creatorcontrib>SANTA,JOZSEFNE,HU</creatorcontrib><creatorcontrib>NAD,ZSUZSANNA,HU</creatorcontrib><creatorcontrib>BESENYEI,GABOR,HU</creatorcontrib><creatorcontrib>GYOERY,PETER,HU</creatorcontrib><creatorcontrib>JELINEK,ISTVAN,HU</creatorcontrib><creatorcontrib>KALLAY U.,TAMAS,HU</creatorcontrib><title>PROCESS FOR PRODUCING DOXYCYCLINE</title><description>PCT No. PCT/HU88/00063 Sec. 371 Date May 5, 1989 Sec. 102(e) Date May 5, 1989 PCT Filed Sep. 16, 1988 PCT Pub. 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Date Mar. 23, 1989.The invention relates to a process for the preparation of tetracycline derivatives of the formula I. and acid addition salts thereof -wherein R stands for -CH3 or =CH2-by dehalogenating and hydrogenating chloromethacycline or acid addition salt thereof of the formula II. or by hydrating methacycline or acid addition salts thereof of the formula III. by treatment with hydrogen gas in the presence of a noble metal alloy catalyst on carrier and organic solvent which comprises performing, hydrogenating under pressure of 0.1-1.0 MPa with an alloy catalyst consisting of the alloy palladium or platinum and selenium and/or tellurium used at a ratio of 1:0.01-0.5 related to the amount of the starting tetracycline and carrying out, if desired dehalogenation and hydrogenation in one step.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>APPARATUS THEREFOR</subject><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>THEIR RELEVANT APPARATUS</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1989</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAMCPJ3dg0OVnDzD1IAsl1CnT393BVc_CMinSOdfTz9XHkYWNMSc4pTeaE0N4Ocm2uIs4duakF-fGpxQWJyal5qSbxHqKGlhaG5sZMxQQUAbukhUg</recordid><startdate>19890828</startdate><enddate>19890828</enddate><creator>SIMONIDESZ,VILMOS,HU</creator><creator>NAGY,LAJOS,HU</creator><creator>LUGOSI,MARTA,HU</creator><creator>LUGOSI,GYOERGY,HU</creator><creator>SIMANDI,LASZLO,HU</creator><creator>SZALAY,ERZSEBET,HU</creator><creator>SANTA,JOZSEFNE,HU</creator><creator>NAD,ZSUZSANNA,HU</creator><creator>BESENYEI,GABOR,HU</creator><creator>GYOERY,PETER,HU</creator><creator>JELINEK,ISTVAN,HU</creator><creator>KALLAY U.,TAMAS,HU</creator><scope>EVB</scope></search><sort><creationdate>19890828</creationdate><title>PROCESS FOR PRODUCING DOXYCYCLINE</title><author>SIMONIDESZ,VILMOS,HU ; NAGY,LAJOS,HU ; LUGOSI,MARTA,HU ; LUGOSI,GYOERGY,HU ; SIMANDI,LASZLO,HU ; SZALAY,ERZSEBET,HU ; SANTA,JOZSEFNE,HU ; NAD,ZSUZSANNA,HU ; BESENYEI,GABOR,HU ; GYOERY,PETER,HU ; JELINEK,ISTVAN,HU ; KALLAY U.,TAMAS,HU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HU198173B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1989</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>APPARATUS THEREFOR</topic><topic>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>THEIR RELEVANT APPARATUS</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>SIMONIDESZ,VILMOS,HU</creatorcontrib><creatorcontrib>NAGY,LAJOS,HU</creatorcontrib><creatorcontrib>LUGOSI,MARTA,HU</creatorcontrib><creatorcontrib>LUGOSI,GYOERGY,HU</creatorcontrib><creatorcontrib>SIMANDI,LASZLO,HU</creatorcontrib><creatorcontrib>SZALAY,ERZSEBET,HU</creatorcontrib><creatorcontrib>SANTA,JOZSEFNE,HU</creatorcontrib><creatorcontrib>NAD,ZSUZSANNA,HU</creatorcontrib><creatorcontrib>BESENYEI,GABOR,HU</creatorcontrib><creatorcontrib>GYOERY,PETER,HU</creatorcontrib><creatorcontrib>JELINEK,ISTVAN,HU</creatorcontrib><creatorcontrib>KALLAY U.,TAMAS,HU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SIMONIDESZ,VILMOS,HU</au><au>NAGY,LAJOS,HU</au><au>LUGOSI,MARTA,HU</au><au>LUGOSI,GYOERGY,HU</au><au>SIMANDI,LASZLO,HU</au><au>SZALAY,ERZSEBET,HU</au><au>SANTA,JOZSEFNE,HU</au><au>NAD,ZSUZSANNA,HU</au><au>BESENYEI,GABOR,HU</au><au>GYOERY,PETER,HU</au><au>JELINEK,ISTVAN,HU</au><au>KALLAY U.,TAMAS,HU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PRODUCING DOXYCYCLINE</title><date>1989-08-28</date><risdate>1989</risdate><abstract>PCT No. PCT/HU88/00063 Sec. 371 Date May 5, 1989 Sec. 102(e) Date May 5, 1989 PCT Filed Sep. 16, 1988 PCT Pub. No. WO89/02429 PCT Pub. Date Mar. 23, 1989.The invention relates to a process for the preparation of tetracycline derivatives of the formula I. and acid addition salts thereof -wherein R stands for -CH3 or =CH2-by dehalogenating and hydrogenating chloromethacycline or acid addition salt thereof of the formula II. or by hydrating methacycline or acid addition salts thereof of the formula III. by treatment with hydrogen gas in the presence of a noble metal alloy catalyst on carrier and organic solvent which comprises performing, hydrogenating under pressure of 0.1-1.0 MPa with an alloy catalyst consisting of the alloy palladium or platinum and selenium and/or tellurium used at a ratio of 1:0.01-0.5 related to the amount of the starting tetracycline and carrying out, if desired dehalogenation and hydrogenation in one step.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING |
| title | PROCESS FOR PRODUCING DOXYCYCLINE |
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