PROCESS FOR PRODUCING LOW VISCOSITY, HIGH MOLECULE HYALURONIC ACID STERILIZABLE WITH FILTERING

PROCESS FOR PRODUCING LOW VISCOSITY, HIGH MOLECULE HYALURONIC ACID STERILIZABLE WITH FILTERING

Processes for adjusting the average molecular weight, the molecular weight distribution and the viscosity in solutions of hyaluronic acid and its salts (HA), especially its sodium and potassium salts, entail, to increase the average molecular weight and restrict the molecular weight distribution, th...

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Hauptverfasser: TRUMP L,SANDY,US, BRYANT A,SHARON,US, GREENE D,NATHAN,US, BROWN,KAREN K.,US
Format: Patent
Sprache:eng
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CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
THEIR PREPARATION OR CHEMICAL WORKING-UP
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creator TRUMP L,SANDY,US
BRYANT A,SHARON,US
GREENE D,NATHAN,US
BROWN,KAREN K.,US
description Processes for adjusting the average molecular weight, the molecular weight distribution and the viscosity in solutions of hyaluronic acid and its salts (HA), especially its sodium and potassium salts, entail, to increase the average molecular weight and restrict the molecular weight distribution, this material being precipitated in a bath of a nonsolvent which contains a continuously moving device to which it can adhere on precipitation. The solution viscosity of this or any other high molecular weight high viscosity HA can be reduced, with a negligible effect on its molecular weight, either by a heat treatment at moderate temperature or by passing an aqueous solution of 1% by weight or stronger through a fine-pore (1  mu m or less) filter.
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subjects CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
THEIR PREPARATION OR CHEMICAL WORKING-UP
title PROCESS FOR PRODUCING LOW VISCOSITY, HIGH MOLECULE HYALURONIC ACID STERILIZABLE WITH FILTERING
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