PROCESS FOR PRODUCTION OF DERIVATIVES OF 7-OXO-PROSTACYCLIN WITH SELECTIVE BIOLOGICAL EFFECT

Compounds of the formula I are disclosed wherein R1 stands for hydrogen, C1-4 straight or branched alkyl or pharmacologically acceptable cation, R2 stands for hydrogen, C1-4 alkanoyl, benzoyl, or benzoyl substituted by C1-4 alkyl or halogen, and R2 can further represent tetrahydropyranyl, trialkylsi...

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Bibliographische Detailangaben
Hauptverfasser:	IVANICS,JOZSEF,HU, VIRAG,SANDOR,HU, GALAMBOS,GEZA,HU, KOERMOECZY,PETER,HU, TOEMOESKOEZI,ISTVAN,HU, KOVACS,MARIANN,HU, STADLER,ISTVAN,HU, KOVACS,GABOR,HU, GYOERI,PETER,HU, KANAI,KAROLY,HU, DORMAN,GYOERGY,HU
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of the formula I are disclosed wherein R1 stands for hydrogen, C1-4 straight or branched alkyl or pharmacologically acceptable cation, R2 stands for hydrogen, C1-4 alkanoyl, benzoyl, or benzoyl substituted by C1-4 alkyl or halogen, and R2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl, A stands for ethylene, cis or trans-vinylene or -C=C-, n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.