PROCESS FOR PRODUCING 4-AMINO-3-QUINOLINE CARBOXYLIC ACIDS AND ESTERS

Aminoquinolinecarboxylates I (R1=alkyl, Ph, o-alkyl, s-alkyl, halo, CF3, cyano, dialkylamino; R2=alkyl, Ph, phenylalkyl, o-alkyl, s-alkyl, halo, cyano, OH, carbamoyl, carboxy, acetyl, CF3, nitro; R3=H, alkyl, alkyldimethylamino, alkoxyalkyl, allyl; n=0-2) were prepd. Thus, 5.31g ethyl 4-chloro-8-met...

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Hauptverfasser:	ALPHIN,REEVIS S.,US, MUNSON,HARRY R.,US
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	ALPHIN,REEVIS S.,US MUNSON,HARRY R.,US
description	Aminoquinolinecarboxylates I (R1=alkyl, Ph, o-alkyl, s-alkyl, halo, CF3, cyano, dialkylamino; R2=alkyl, Ph, phenylalkyl, o-alkyl, s-alkyl, halo, cyano, OH, carbamoyl, carboxy, acetyl, CF3, nitro; R3=H, alkyl, alkyldimethylamino, alkoxyalkyl, allyl; n=0-2) were prepd. Thus, 5.31g ethyl 4-chloro-8-methoxy-3-quinolinecarboxylate in 40mL THF was reacted with 2.12g o-toluidine in 40mL THF at 60 C for 18 hrs. to give 7.13g ethyl 8-methoxy-4-[(2-methylphenyl)amino -3-quinoline-carboxylate. HCl.
format	Patent
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Thus, 5.31g ethyl 4-chloro-8-methoxy-3-quinolinecarboxylate in 40mL THF was reacted with 2.12g o-toluidine in 40mL THF at 60 C for 18 hrs. to give 7.13g ethyl 8-methoxy-4-[(2-methylphenyl)amino -3-quinoline-carboxylate. HCl.</description><edition>3</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1984</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19840730&DB=EPODOC&CC=HU&NR=184253B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19840730&DB=EPODOC&CC=HU&NR=184253B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ALPHIN,REEVIS S.,US</creatorcontrib><creatorcontrib>MUNSON,HARRY R.,US</creatorcontrib><title>PROCESS FOR PRODUCING 4-AMINO-3-QUINOLINE CARBOXYLIC ACIDS AND ESTERS</title><description>Aminoquinolinecarboxylates I (R1=alkyl, Ph, o-alkyl, s-alkyl, halo, CF3, cyano, dialkylamino; R2=alkyl, Ph, phenylalkyl, o-alkyl, s-alkyl, halo, cyano, OH, carbamoyl, carboxy, acetyl, CF3, nitro; R3=H, alkyl, alkyldimethylamino, alkoxyalkyl, allyl; n=0-2) were prepd. Thus, 5.31g ethyl 4-chloro-8-methoxy-3-quinolinecarboxylate in 40mL THF was reacted with 2.12g o-toluidine in 40mL THF at 60 C for 18 hrs. to give 7.13g ethyl 8-methoxy-4-[(2-methylphenyl)amino -3-quinoline-carboxylate. HCl.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1984</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHANCPJ3dg0OVnDzD1IAsl1CnT393BVMdB19Pf38dY11A0OBtI-nn6uCs2OQk39EpI-ns4Kjs6dLsIKjn4uCa3CIa1AwDwNrWmJOcSovlOZmkHNzDXH20E0tyI9PLS5ITE7NSy2J9wg1tDAxMjV2MiaoAAByyyqy</recordid><startdate>19840730</startdate><enddate>19840730</enddate><creator>ALPHIN,REEVIS S.,US</creator><creator>MUNSON,HARRY R.,US</creator><scope>EVB</scope></search><sort><creationdate>19840730</creationdate><title>PROCESS FOR PRODUCING 4-AMINO-3-QUINOLINE CARBOXYLIC ACIDS AND ESTERS</title><author>ALPHIN,REEVIS S.,US ; MUNSON,HARRY R.,US</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HU184253B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1984</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ALPHIN,REEVIS S.,US</creatorcontrib><creatorcontrib>MUNSON,HARRY R.,US</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ALPHIN,REEVIS S.,US</au><au>MUNSON,HARRY R.,US</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PRODUCING 4-AMINO-3-QUINOLINE CARBOXYLIC ACIDS AND ESTERS</title><date>1984-07-30</date><risdate>1984</risdate><abstract>Aminoquinolinecarboxylates I (R1=alkyl, Ph, o-alkyl, s-alkyl, halo, CF3, cyano, dialkylamino; R2=alkyl, Ph, phenylalkyl, o-alkyl, s-alkyl, halo, cyano, OH, carbamoyl, carboxy, acetyl, CF3, nitro; R3=H, alkyl, alkyldimethylamino, alkoxyalkyl, allyl; n=0-2) were prepd. Thus, 5.31g ethyl 4-chloro-8-methoxy-3-quinolinecarboxylate in 40mL THF was reacted with 2.12g o-toluidine in 40mL THF at 60 C for 18 hrs. to give 7.13g ethyl 8-methoxy-4-[(2-methylphenyl)amino -3-quinoline-carboxylate. HCl.</abstract><edition>3</edition><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	PROCESS FOR PRODUCING 4-AMINO-3-QUINOLINE CARBOXYLIC ACIDS AND ESTERS
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