PROCESS FOR PRODUCING 4-AMINO-3-QUINOLINE CARBOXYLIC ACIDS AND ESTERS

PROCESS FOR PRODUCING 4-AMINO-3-QUINOLINE CARBOXYLIC ACIDS AND ESTERS

Aminoquinolinecarboxylates I (R1=alkyl, Ph, o-alkyl, s-alkyl, halo, CF3, cyano, dialkylamino; R2=alkyl, Ph, phenylalkyl, o-alkyl, s-alkyl, halo, cyano, OH, carbamoyl, carboxy, acetyl, CF3, nitro; R3=H, alkyl, alkyldimethylamino, alkoxyalkyl, allyl; n=0-2) were prepd. Thus, 5.31g ethyl 4-chloro-8-met...

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Bibliographische Detailangaben
Hauptverfasser: ALPHIN,REEVIS S.,US, MUNSON,HARRY R.,US
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Aminoquinolinecarboxylates I (R1=alkyl, Ph, o-alkyl, s-alkyl, halo, CF3, cyano, dialkylamino; R2=alkyl, Ph, phenylalkyl, o-alkyl, s-alkyl, halo, cyano, OH, carbamoyl, carboxy, acetyl, CF3, nitro; R3=H, alkyl, alkyldimethylamino, alkoxyalkyl, allyl; n=0-2) were prepd. Thus, 5.31g ethyl 4-chloro-8-methoxy-3-quinolinecarboxylate in 40mL THF was reacted with 2.12g o-toluidine in 40mL THF at 60 C for 18 hrs. to give 7.13g ethyl 8-methoxy-4-[(2-methylphenyl)amino -3-quinoline-carboxylate. HCl.