PROCESS FOR PRODUCING SUBSTITUTED 3-ALKYL-6-PHENYL-1,2,4-TRIASOLO-BRACKET-4,3-A-BRACKET CLOSED-PYRIDINES

PROCESS FOR PRODUCING SUBSTITUTED 3-ALKYL-6-PHENYL-1,2,4-TRIASOLO-BRACKET-4,3-A-BRACKET CLOSED-PYRIDINES

There are provided novel 3-alkyl-6-(substituted-phenyl)-1,2,4-triazolo[4,3-a]pyridines useful as anxiolytic agents, processes for their preparation and pharmaceutical compositions containing them. The compounds have the formula: wherein R1 is hydrogen, alkyl (C1-C4), alkoxy (C1-C4), fluoro, chloro,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ALBRIGHT,JAY,D.,US, TRUST,RONALD,I.,US
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
INFORMATION STORAGE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STATIC STORES
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Beschreibung
Zusammenfassung:There are provided novel 3-alkyl-6-(substituted-phenyl)-1,2,4-triazolo[4,3-a]pyridines useful as anxiolytic agents, processes for their preparation and pharmaceutical compositions containing them. The compounds have the formula: wherein R1 is hydrogen, alkyl (C1-C4), alkoxy (C1-C4), fluoro, chloro, bromo, trifluoromethyl, cyano, carboxy, alkoxycarbonyl (C2-C5), carboxamido, nitro, amino, acylamino (C1-C4), monoalkylamino (C1-C4) or dialkylamino wherein each alkyl group has up to 4 carbon atoms and R2 is alkyl (C1-C3); or a pharmacologically acceptable acid-addition salt thereof.