NEW IMIDAZOLINE DERIVATIVES, THEIR PREPARATION AND USE, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Imidazolidine derivatives of formula (I) and their stereoisomers and salts are new. W = C(R13)AR1 or C=CHR1; Z = O or S; a = direct bond or 1-2C alkylene; B = 1-6C alkylene (optionally substituted by 1-8C alkyl), 2-8C alkenyl, 2-8C alkynyl, 3-10C cycloalkyl, (3-10C)cycloalkyl(1-6C)alkyl, optionally substituted 6-14C aryl, optionally ring-substituted (6-14C)aryl(1-6C)alkyl, optionally substituted heteroaryl or optionally ring-substituted heteroaryl(1-6C)alkyl, 2-6C alkenylene, phenylene, phenylene(1-3C)alkylene or (1-3C)alkylenephenylene; E = tetrazolyl, PO(OR8)2, SO3H, SO2NHR9 or COR10; R = H, 1-8C alkyl, 3-12C cycloalkyl, (3-12C)cycloalkyl(1-8C)alkyl, optionally substituted 6-14C aryl, optionally ring-substituted (6-14C)aryl(1-8C)alkyl, optionally substituted heteroaryl or optionally ring-substituted heteroaryl(1-8C)alkyl; R10 = H, R', CHO, COR', SOR' or SO2R'; R' = 1-8C alkyl, 3-12C cycloalkyl, (3-12C)cycloalkyl(1-8C)alkyl, 6-12C bicycloalkyl, (6-12C)bicycloalkyl(1-8C)alkyl, 6-12C tricycloalkyl, (6-12C)tricycloalkyl(1-8C)alkyl, optionally substituted 6-14C aryl, optionally ring-substituted (6-14C)aryl(1-8C)alkyl, optionally substituted heteroaryl or optionally ring-substituted heteroaryl(1-8C)alkyl; R1 = optionally substituted and optionally benzo-fused phenyl, furyl, thienyl, pyrrolyl, imidazolyl or pyridyl; R2 = H, 1-8C alkyl, optionally substituted 6-14C aryl, optionally ring-substituted (6-14C)aryl(1-8C)alkyl or 3-8C cycloalkyl; R3 = H, 1-8C alkyl, optionally substituted 6-14C aryl, optionally ring-substituted (6-14C)aryl(1-8C)alkyl, optionally substituted heteroaryl, optionally ring-substituted heteroaryl(1-8C)alkyl, 3-8C cycloalkyl, (3-8C)cycloalkyl(1-8C)alkyl, 6-12C bicycloalkyl, (6-12C)bicycloalkyl(1-8C)alkyl, 6-12C tricycloalkyl, (6-12C)tricycloalkyl(1-8C)alkyl, 2-8C alkenyl, 2-8C alkynyl, NHR11, CON(Me)R4, CONHR4, COOR14, CON(Me)R15 or CONHR15; R4 = H or 1-10C alkyl (optionally substituted by one or more of OH, 1-8C alkyl, R5, optionally substituted 3-8C cycloalkyl, COOH, CONH2, mono- or di(1-18C alkyl)carbamoyl, optionally ring-substituted (6-14C)aryl(2-9C)alkoxycarbonyl, 2-9C alkoxycarbonyl, CO-Het, COR6, tetrazolyl and CF3); R5 = optionally substituted 6-14C aryl, optionally ring-substituted (6-14C)aryl(1-8C)alkyl or optionally substituted mono- or bicyclic 5-12-membered heterocyclyl containing 1-3 heteroatoms selected from N, O and S; R6 = optionally protected residue of an amino acid, imino acid, optionally N-(1-8C)-alkylated or N-(optiona