TUMORICIDEBIS-IMIDE POLYCYCLIC AND HETEROCYCLIC CHROMOPHORES USEFUL AS TUMORICIDALS

Anticancer compounds of formula I: (I) and pharmaceutically acceptable salts thereof, wherein: R1, R2 and R3 are independently selected H, CH3, NH2, NO2, and CN; R9 and R10 are H or alkyl or halo, X1 and Y1 or X2 and Y2, when present, join together to form, independently, a six membered 1N heterocyc...

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Hauptverfasser:	STEVEN PAUL SEITZ, MICHAEL JAMES ORWAT, EMEKA AMAECHI AKAMIKE, ARTUR DAVID PATTEN, GREGORY PACOFSKY, ROBERT JOSEPH CHERNEY, ROBERT FRANK KALTENBACH
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Anticancer compounds of formula I: (I) and pharmaceutically acceptable salts thereof, wherein: R1, R2 and R3 are independently selected H, CH3, NH2, NO2, and CN; R9 and R10 are H or alkyl or halo, X1 and Y1 or X2 and Y2, when present, join together to form, independently, a six membered 1N heterocycle substituted with 1-2 R3; or the group: wherein one of W or Z is C=O and the other is C=O, NH, S or O; or when X2 and Y2 are not joined together and when R2 is in the 4-position, then X2 and R2 may join together to form an ethylene bridge; are disclosed.