A PROCESS FOR THE PREPARATION OF 9-SUBSTITUTED GUANINE DERIVATIVES AND INTERMEDIATES FOR USE IN THE PROCESS
PCT No. PCT/DK90/00077 Sec. 371 Date Sep. 20, 1991 Sec. 102(e) Date Sep. 20, 1991 PCT Filed Mar. 19, 1990 PCT Pub. No. WO90/11283 PCT Pub. Date Oct. 4, 1990.A process for the preparation of 9-substituted quanine derivatives of general formula (I), in which R is C1-C4-alkyl optionally substituted wit...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | hrv ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | Juhl-Christensen, Jorgen McCluskey, Klaus K Alhede, Borge Clausen, Finn Priess Preikschat, Herbert Fritz |
| description | PCT No. PCT/DK90/00077 Sec. 371 Date Sep. 20, 1991 Sec. 102(e) Date Sep. 20, 1991 PCT Filed Mar. 19, 1990 PCT Pub. No. WO90/11283 PCT Pub. Date Oct. 4, 1990.A process for the preparation of 9-substituted quanine derivatives of general formula (I), in which R is C1-C4-alkyl optionally substituted with one or more hydroxy groups, or R is ( alpha ), benzyl, ribosyl, 2'-deoxyribosyl or (CH2)n-OR1 where n is 1 or 2, and R1is CH2CH2OH or ( beta ) or salts thereof, in which a 1-substituted5-(thiocarbamoyl)amino-1H-imidazole-4-carboxamide of general formula (III), where R has the same meaning as in formula (I), is cyclized: a) by treatment with a heavy metal salt of the group of Cu-, Ag-, Pb- and Hg-salts in an aqueous alkaline medium containing at least for equivalents of OH-ions at a temperature form about 0 DEG C. to the reflux temperature, or b) by treatment with a peroxy compound in an aqueous alkaline medium at a temperature of about 0 DEG -30 DEG C., whereafter (I) is isolated by treatment with a acid and, if desired, is converted into a salt. The invention further comprises intermediates for use in the preparation of the above-mentioned compounds. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_HRP920907A2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>HRP920907A2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_HRP920907A23</originalsourceid><addsrcrecordid>eNqNjUEKwjAQRbtxIeod5gKFUheS5dhMTBYmIZl0W0qJG0UL9f4YtAdw9fmfx_vb6o7gg-soRlAuAGsqnTwGZOMsOAWijukc2XBiknBJaI0lkBRMX5ieIqCVYCxTuJI0yPRTpUhlXY3fh321uY2PJR_W3FWgiDtd5_k15GUep_zM70EHL9pGNCdsj38gH1BBNj0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>A PROCESS FOR THE PREPARATION OF 9-SUBSTITUTED GUANINE DERIVATIVES AND INTERMEDIATES FOR USE IN THE PROCESS</title><source>esp@cenet</source><creator>Juhl-Christensen, Jorgen ; McCluskey, Klaus K ; Alhede, Borge ; Clausen, Finn Priess ; Preikschat, Herbert Fritz</creator><creatorcontrib>Juhl-Christensen, Jorgen ; McCluskey, Klaus K ; Alhede, Borge ; Clausen, Finn Priess ; Preikschat, Herbert Fritz</creatorcontrib><description>PCT No. PCT/DK90/00077 Sec. 371 Date Sep. 20, 1991 Sec. 102(e) Date Sep. 20, 1991 PCT Filed Mar. 19, 1990 PCT Pub. No. WO90/11283 PCT Pub. Date Oct. 4, 1990.A process for the preparation of 9-substituted quanine derivatives of general formula (I), in which R is C1-C4-alkyl optionally substituted with one or more hydroxy groups, or R is ( alpha ), benzyl, ribosyl, 2'-deoxyribosyl or (CH2)n-OR1 where n is 1 or 2, and R1is CH2CH2OH or ( beta ) or salts thereof, in which a 1-substituted5-(thiocarbamoyl)amino-1H-imidazole-4-carboxamide of general formula (III), where R has the same meaning as in formula (I), is cyclized: a) by treatment with a heavy metal salt of the group of Cu-, Ag-, Pb- and Hg-salts in an aqueous alkaline medium containing at least for equivalents of OH-ions at a temperature form about 0 DEG C. to the reflux temperature, or b) by treatment with a peroxy compound in an aqueous alkaline medium at a temperature of about 0 DEG -30 DEG C., whereafter (I) is isolated by treatment with a acid and, if desired, is converted into a salt. The invention further comprises intermediates for use in the preparation of the above-mentioned compounds.</description><language>hrv ; eng</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; SUGARS</subject><creationdate>1994</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19940430&DB=EPODOC&CC=HR&NR=P920907A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19940430&DB=EPODOC&CC=HR&NR=P920907A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Juhl-Christensen, Jorgen</creatorcontrib><creatorcontrib>McCluskey, Klaus K</creatorcontrib><creatorcontrib>Alhede, Borge</creatorcontrib><creatorcontrib>Clausen, Finn Priess</creatorcontrib><creatorcontrib>Preikschat, Herbert Fritz</creatorcontrib><title>A PROCESS FOR THE PREPARATION OF 9-SUBSTITUTED GUANINE DERIVATIVES AND INTERMEDIATES FOR USE IN THE PROCESS</title><description>PCT No. PCT/DK90/00077 Sec. 371 Date Sep. 20, 1991 Sec. 102(e) Date Sep. 20, 1991 PCT Filed Mar. 19, 1990 PCT Pub. No. WO90/11283 PCT Pub. Date Oct. 4, 1990.A process for the preparation of 9-substituted quanine derivatives of general formula (I), in which R is C1-C4-alkyl optionally substituted with one or more hydroxy groups, or R is ( alpha ), benzyl, ribosyl, 2'-deoxyribosyl or (CH2)n-OR1 where n is 1 or 2, and R1is CH2CH2OH or ( beta ) or salts thereof, in which a 1-substituted5-(thiocarbamoyl)amino-1H-imidazole-4-carboxamide of general formula (III), where R has the same meaning as in formula (I), is cyclized: a) by treatment with a heavy metal salt of the group of Cu-, Ag-, Pb- and Hg-salts in an aqueous alkaline medium containing at least for equivalents of OH-ions at a temperature form about 0 DEG C. to the reflux temperature, or b) by treatment with a peroxy compound in an aqueous alkaline medium at a temperature of about 0 DEG -30 DEG C., whereafter (I) is isolated by treatment with a acid and, if desired, is converted into a salt. The invention further comprises intermediates for use in the preparation of the above-mentioned compounds.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1994</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjUEKwjAQRbtxIeod5gKFUheS5dhMTBYmIZl0W0qJG0UL9f4YtAdw9fmfx_vb6o7gg-soRlAuAGsqnTwGZOMsOAWijukc2XBiknBJaI0lkBRMX5ieIqCVYCxTuJI0yPRTpUhlXY3fh321uY2PJR_W3FWgiDtd5_k15GUep_zM70EHL9pGNCdsj38gH1BBNj0</recordid><startdate>19940430</startdate><enddate>19940430</enddate><creator>Juhl-Christensen, Jorgen</creator><creator>McCluskey, Klaus K</creator><creator>Alhede, Borge</creator><creator>Clausen, Finn Priess</creator><creator>Preikschat, Herbert Fritz</creator><scope>EVB</scope></search><sort><creationdate>19940430</creationdate><title>A PROCESS FOR THE PREPARATION OF 9-SUBSTITUTED GUANINE DERIVATIVES AND INTERMEDIATES FOR USE IN THE PROCESS</title><author>Juhl-Christensen, Jorgen ; McCluskey, Klaus K ; Alhede, Borge ; Clausen, Finn Priess ; Preikschat, Herbert Fritz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HRP920907A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>hrv ; eng</language><creationdate>1994</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>Juhl-Christensen, Jorgen</creatorcontrib><creatorcontrib>McCluskey, Klaus K</creatorcontrib><creatorcontrib>Alhede, Borge</creatorcontrib><creatorcontrib>Clausen, Finn Priess</creatorcontrib><creatorcontrib>Preikschat, Herbert Fritz</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Juhl-Christensen, Jorgen</au><au>McCluskey, Klaus K</au><au>Alhede, Borge</au><au>Clausen, Finn Priess</au><au>Preikschat, Herbert Fritz</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A PROCESS FOR THE PREPARATION OF 9-SUBSTITUTED GUANINE DERIVATIVES AND INTERMEDIATES FOR USE IN THE PROCESS</title><date>1994-04-30</date><risdate>1994</risdate><abstract>PCT No. PCT/DK90/00077 Sec. 371 Date Sep. 20, 1991 Sec. 102(e) Date Sep. 20, 1991 PCT Filed Mar. 19, 1990 PCT Pub. No. WO90/11283 PCT Pub. Date Oct. 4, 1990.A process for the preparation of 9-substituted quanine derivatives of general formula (I), in which R is C1-C4-alkyl optionally substituted with one or more hydroxy groups, or R is ( alpha ), benzyl, ribosyl, 2'-deoxyribosyl or (CH2)n-OR1 where n is 1 or 2, and R1is CH2CH2OH or ( beta ) or salts thereof, in which a 1-substituted5-(thiocarbamoyl)amino-1H-imidazole-4-carboxamide of general formula (III), where R has the same meaning as in formula (I), is cyclized: a) by treatment with a heavy metal salt of the group of Cu-, Ag-, Pb- and Hg-salts in an aqueous alkaline medium containing at least for equivalents of OH-ions at a temperature form about 0 DEG C. to the reflux temperature, or b) by treatment with a peroxy compound in an aqueous alkaline medium at a temperature of about 0 DEG -30 DEG C., whereafter (I) is isolated by treatment with a acid and, if desired, is converted into a salt. The invention further comprises intermediates for use in the preparation of the above-mentioned compounds.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | hrv ; eng |
| recordid | cdi_epo_espacenet_HRP920907A2 |
| source | esp@cenet |
| subjects | CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS |
| title | A PROCESS FOR THE PREPARATION OF 9-SUBSTITUTED GUANINE DERIVATIVES AND INTERMEDIATES FOR USE IN THE PROCESS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T10%3A22%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Juhl-Christensen,%20Jorgen&rft.date=1994-04-30&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EHRP920907A2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |