A TABLET COMPRISING A METHOXYUREA DERIVATIVE AND MANNITOL PARTICLES

A TABLET COMPRISING A METHOXYUREA DERIVATIVE AND MANNITOL PARTICLES

Provided is a solid preparation showing improved stability of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-methoxyurea and a salt thereof in the solid preparation, and a method of stabilizin...

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Hauptverfasser: Yamane, Ikuro, Nishimoto, Yutaka, Hoshina, Wataru, Nomura, Yukihiro
Format: Patent
Sprache:hrv ; eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator Yamane, Ikuro
Nishimoto, Yutaka
Hoshina, Wataru
Nomura, Yukihiro
description Provided is a solid preparation showing improved stability of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-methoxyurea and a salt thereof in the solid preparation, and a method of stabilizing the compound in a solid preparation.A tablet containing not less than 25 mass % of the compound; a solid preparation containing (1) the compound, and (2) a fat and oil-like substance having a low melting point, which is selected from polyethylene glycol, glycerol monostearate and triethyl citrate; a method of stabilizing the compound in a tablet, including adding not less than 25 mass % of the compound; and a method of stabilizing the compound, including adding a fat and oil-like substance having a low melting point, which is selected from polyethylene glycol, glycerol monostearate and triethyl citrate to a solid preparation containing the compound.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title A TABLET COMPRISING A METHOXYUREA DERIVATIVE AND MANNITOL PARTICLES
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