CD73 INHIBITORS

The present invention provides 5-[5]-[2-cycloalkyl]-6-pyridazin-3-yl]-1H-pyrimidine-2,4-dione compounds, or pharmaceutically acceptable salts thereof, that inhibit the activity of CD73 and are useful in treating cancer.

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Hauptverfasser: Garcia Paredes, Maria Cristina, Wang, Yan, Heinz, Lawrence Joseph II, Zhao, Genshi, Njoroge, Frank George, Howell, Jennifer Marie, Dally, Robert Dean
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creator Garcia Paredes, Maria Cristina
Wang, Yan
Heinz, Lawrence Joseph II
Zhao, Genshi
Njoroge, Frank George
Howell, Jennifer Marie
Dally, Robert Dean
description The present invention provides 5-[5]-[2-cycloalkyl]-6-pyridazin-3-yl]-1H-pyrimidine-2,4-dione compounds, or pharmaceutically acceptable salts thereof, that inhibit the activity of CD73 and are useful in treating cancer.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title CD73 INHIBITORS
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