MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS
The present invention relates with a process for preparing compounds of Formula I:and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R, R, R, R, and Z are as defined herein, and which are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflamma...
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| creator | Yang, Hong-Woon Zhao, Qian Andrews, Steven Wade Jiang, Yutong Seo, Jeongbeob Condroski, Kevin Ronald Haas, Julia Kolakowski, Gabrielle R |
| description | The present invention relates with a process for preparing compounds of Formula I:and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R, R, R, R, and Z are as defined herein, and which are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases;intermediates of formula IIused in the preparation of compounds of formula I and the compound for use in the treatment of the diseases mentioned above of the following formula: |
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Kolakowski, Gabrielle R</creatorcontrib><description>The present invention relates with a process for preparing compounds of Formula I:and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R, R, R, R, and Z are as defined herein, and which are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases;intermediates of formula IIused in the preparation of compounds of formula I and the compound for use in the treatment of the diseases mentioned above of the following formula:</description><language>hrv ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190614&DB=EPODOC&CC=HR&NR=P20190559T1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190614&DB=EPODOC&CC=HR&NR=P20190559T1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Yang, Hong-Woon</creatorcontrib><creatorcontrib>Zhao, Qian</creatorcontrib><creatorcontrib>Andrews, Steven Wade</creatorcontrib><creatorcontrib>Jiang, Yutong</creatorcontrib><creatorcontrib>Seo, Jeongbeob</creatorcontrib><creatorcontrib>Condroski, Kevin Ronald</creatorcontrib><creatorcontrib>Haas, Julia</creatorcontrib><creatorcontrib>Kolakowski, Gabrielle R</creatorcontrib><title>MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS</title><description>The present invention relates with a process for preparing compounds of Formula I:and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R, R, R, R, and Z are as defined herein, and which are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases;intermediates of formula IIused in the preparation of compounds of formula I and the compound for use in the treatment of the diseases mentioned above of the following formula:</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNDzdXQO8neOdPbxdFZw9vcN8A_1cwlWcAxWCAnyVvD29HMMdlXw9PPwdPIM8Q8K5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8R5BAUYGhpYGpqaWISGGxsSpAgCShidV</recordid><startdate>20190614</startdate><enddate>20190614</enddate><creator>Yang, Hong-Woon</creator><creator>Zhao, Qian</creator><creator>Andrews, Steven Wade</creator><creator>Jiang, Yutong</creator><creator>Seo, Jeongbeob</creator><creator>Condroski, Kevin Ronald</creator><creator>Haas, Julia</creator><creator>Kolakowski, Gabrielle R</creator><scope>EVB</scope></search><sort><creationdate>20190614</creationdate><title>MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS</title><author>Yang, Hong-Woon ; Zhao, Qian ; Andrews, Steven Wade ; Jiang, Yutong ; Seo, Jeongbeob ; Condroski, Kevin Ronald ; Haas, Julia ; Kolakowski, Gabrielle R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HRP20190559TT13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>hrv ; eng</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>Yang, Hong-Woon</creatorcontrib><creatorcontrib>Zhao, Qian</creatorcontrib><creatorcontrib>Andrews, Steven Wade</creatorcontrib><creatorcontrib>Jiang, Yutong</creatorcontrib><creatorcontrib>Seo, Jeongbeob</creatorcontrib><creatorcontrib>Condroski, Kevin Ronald</creatorcontrib><creatorcontrib>Haas, Julia</creatorcontrib><creatorcontrib>Kolakowski, Gabrielle R</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Yang, Hong-Woon</au><au>Zhao, Qian</au><au>Andrews, Steven Wade</au><au>Jiang, Yutong</au><au>Seo, Jeongbeob</au><au>Condroski, Kevin Ronald</au><au>Haas, Julia</au><au>Kolakowski, Gabrielle R</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS</title><date>2019-06-14</date><risdate>2019</risdate><abstract>The present invention relates with a process for preparing compounds of Formula I:and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R, R, R, R, and Z are as defined herein, and which are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases;intermediates of formula IIused in the preparation of compounds of formula I and the compound for use in the treatment of the diseases mentioned above of the following formula:</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS |
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