TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS
TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Compounds of formula I wherein: R 1 is and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase an...
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| creator | Venkatesan, Aranapakam M Delos Santos, Efren Guillermo Zask, Arie Richard, David J Chen, Zecheng Mansour, Tarek S Kaplan, Joshua Aaron Ayral-Kaloustian, Semiramis Dos Santos, Osvaldo Curran, Kevin J Shi, Mengxiao Gopalsamy, Ariamala Verheijen, Jeroen C Dehnhardt, Christoph M |
| description | TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Compounds of formula I
wherein:
R 1 is
and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed. |
| format | Patent |
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wherein:
R 1 is
and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.</description><language>hrv ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170630&DB=EPODOC&CC=HR&NR=P20170637T1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170630&DB=EPODOC&CC=HR&NR=P20170637T1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Venkatesan, Aranapakam M</creatorcontrib><creatorcontrib>Delos Santos, Efren Guillermo</creatorcontrib><creatorcontrib>Zask, Arie</creatorcontrib><creatorcontrib>Richard, David J</creatorcontrib><creatorcontrib>Chen, Zecheng</creatorcontrib><creatorcontrib>Mansour, Tarek S</creatorcontrib><creatorcontrib>Kaplan, Joshua Aaron</creatorcontrib><creatorcontrib>Ayral-Kaloustian, Semiramis</creatorcontrib><creatorcontrib>Dos Santos, Osvaldo</creatorcontrib><creatorcontrib>Curran, Kevin J</creatorcontrib><creatorcontrib>Shi, Mengxiao</creatorcontrib><creatorcontrib>Gopalsamy, Ariamala</creatorcontrib><creatorcontrib>Verheijen, Jeroen C</creatorcontrib><creatorcontrib>Dehnhardt, Christoph M</creatorcontrib><title>TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS</title><description>TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Compounds of formula I
wherein:
R 1 is
and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAJCfJ0jPL0c1Vw9vcN8A_1cwlWcAxWCDA0VvD29HMMdlVw9HNR8A3xD1Lw9PPwdPIEsoJ5GFjTEnOKU3mhNDeDsptriLOHbmpBfnxqcUFicmpeakm8R1CAkYGhuYGZsXlIiKExcaoAW2wopg</recordid><startdate>20170630</startdate><enddate>20170630</enddate><creator>Venkatesan, Aranapakam M</creator><creator>Delos Santos, Efren Guillermo</creator><creator>Zask, Arie</creator><creator>Richard, David J</creator><creator>Chen, Zecheng</creator><creator>Mansour, Tarek S</creator><creator>Kaplan, Joshua Aaron</creator><creator>Ayral-Kaloustian, Semiramis</creator><creator>Dos Santos, Osvaldo</creator><creator>Curran, Kevin J</creator><creator>Shi, Mengxiao</creator><creator>Gopalsamy, Ariamala</creator><creator>Verheijen, Jeroen C</creator><creator>Dehnhardt, Christoph M</creator><scope>EVB</scope></search><sort><creationdate>20170630</creationdate><title>TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS</title><author>Venkatesan, Aranapakam M ; Delos Santos, Efren Guillermo ; Zask, Arie ; Richard, David J ; Chen, Zecheng ; Mansour, Tarek S ; Kaplan, Joshua Aaron ; Ayral-Kaloustian, Semiramis ; Dos Santos, Osvaldo ; Curran, Kevin J ; Shi, Mengxiao ; Gopalsamy, Ariamala ; Verheijen, Jeroen C ; Dehnhardt, Christoph M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HRP20170637TT13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>hrv ; eng</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>Venkatesan, Aranapakam M</creatorcontrib><creatorcontrib>Delos Santos, Efren Guillermo</creatorcontrib><creatorcontrib>Zask, Arie</creatorcontrib><creatorcontrib>Richard, David J</creatorcontrib><creatorcontrib>Chen, Zecheng</creatorcontrib><creatorcontrib>Mansour, Tarek S</creatorcontrib><creatorcontrib>Kaplan, Joshua Aaron</creatorcontrib><creatorcontrib>Ayral-Kaloustian, Semiramis</creatorcontrib><creatorcontrib>Dos Santos, Osvaldo</creatorcontrib><creatorcontrib>Curran, Kevin J</creatorcontrib><creatorcontrib>Shi, Mengxiao</creatorcontrib><creatorcontrib>Gopalsamy, Ariamala</creatorcontrib><creatorcontrib>Verheijen, Jeroen C</creatorcontrib><creatorcontrib>Dehnhardt, Christoph M</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Venkatesan, Aranapakam M</au><au>Delos Santos, Efren Guillermo</au><au>Zask, Arie</au><au>Richard, David J</au><au>Chen, Zecheng</au><au>Mansour, Tarek S</au><au>Kaplan, Joshua Aaron</au><au>Ayral-Kaloustian, Semiramis</au><au>Dos Santos, Osvaldo</au><au>Curran, Kevin J</au><au>Shi, Mengxiao</au><au>Gopalsamy, Ariamala</au><au>Verheijen, Jeroen C</au><au>Dehnhardt, Christoph M</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS</title><date>2017-06-30</date><risdate>2017</risdate><abstract>TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Compounds of formula I
wherein:
R 1 is
and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS |
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