POLYMORPHS OF AN EPOTHILONE ANALOG
Kristalni polimorf analoga epotilona prikazan formulomnaznačen time, što sadrži Oblik A karakteriziran: parametrima jedinične ćelije koji su jednaki slijedećem: Dimenzije ćelije a = 14,152(6) ? b = 30,72(2) ? c = 6,212(3) ? Volumen = 2701 (4) ?3 Prostorna skupina P212121 OrtorombnaMolekula/jedinična...
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| creator | VITEZ IMRE M FAVREAU DENIS ZHENRONG GUO DAVIDOVICH MARTHA DIMARCO JOHN D MALLOY TIMOTHY M GOUGOUTAS JACK Z GALELLA MICHAEL |
| description | Kristalni polimorf analoga epotilona prikazan formulomnaznačen time, što sadrži Oblik A karakteriziran: parametrima jedinične ćelije koji su jednaki slijedećem: Dimenzije ćelije a = 14,152(6) ? b = 30,72(2) ? c = 6,212(3) ? Volumen = 2701 (4) ?3 Prostorna skupina P212121 OrtorombnaMolekula/jedinična ćelija 4Gustoća (izračunata) (g/cm3) 1,247Točka taljenja 182 - 185 °C (razlaganje); ikarakteristični pikovi (vršne vrijednosti) u uzorcima rentgenske difrakcije u prašku vrijednosti od dva theta (CuKa niti λ = 1.5406 ? na 22 °C): 5,69; 6,76; 8,38; 11,43; 12,74; 13,62; 14,35; 15,09; 15,66; 15,43; 17,16; 17,66; 18,31; 19,03; 19,54; 20,57; 21,06; 21,; 22,31; 23,02; 23,66; 24,18; 14,98; 25,50; 26,23; 26,46; 27,59; 28,89; 29,58; 30,32; 31,0 31,52; iliOblik B karakteriziranparametrima jedinične ćelije koji su jednaki slijedećemDimenzije ćelije a = 16,675(2) ? b = 28,083(4) ? c = 6,054(1) ? Volumen = 2835(1) ?3 Prostorna skupina P212121 OrtorombnaMolekule/jedinična ćelija 4Gustoća (izračunana) (g/cm3) 1,184Točka taljenja 191 - 199 °C (razlaganje); ikarakteristični pikovi (vršne vrijednosti) u uzorcima rentgenske difrakcije u prašku pri vrijednosti od dva theta (CuKa niti λ = 1.5406 ? na 22 °C): 6,17; 10,72; 12,33; 14,17; 14,93, 15,88; 16,17; 17,11; 17,98; 19,01; 19,61; 20,38; 21,55; 21,73; 22,48; 23,34; 23,93; 24,78, 25,15; 25,90; 26,63; 27,59; 28,66; 29,55; 30,49 i 31,22. Patent sadrži još 20 patentnih zahtjeva.
There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them. |
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There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them.</description><language>hrv ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110731&DB=EPODOC&CC=HR&NR=P20030190B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110731&DB=EPODOC&CC=HR&NR=P20030190B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VITEZ IMRE M</creatorcontrib><creatorcontrib>FAVREAU DENIS</creatorcontrib><creatorcontrib>ZHENRONG GUO</creatorcontrib><creatorcontrib>DAVIDOVICH MARTHA</creatorcontrib><creatorcontrib>DIMARCO JOHN D</creatorcontrib><creatorcontrib>MALLOY TIMOTHY M</creatorcontrib><creatorcontrib>GOUGOUTAS JACK Z</creatorcontrib><creatorcontrib>GALELLA MICHAEL</creatorcontrib><title>POLYMORPHS OF AN EPOTHILONE ANALOG</title><description>Kristalni polimorf analoga epotilona prikazan formulomnaznačen time, što sadrži Oblik A karakteriziran: parametrima jedinične ćelije koji su jednaki slijedećem: Dimenzije ćelije a = 14,152(6) ? b = 30,72(2) ? c = 6,212(3) ? Volumen = 2701 (4) ?3 Prostorna skupina P212121 OrtorombnaMolekula/jedinična ćelija 4Gustoća (izračunata) (g/cm3) 1,247Točka taljenja 182 - 185 °C (razlaganje); ikarakteristični pikovi (vršne vrijednosti) u uzorcima rentgenske difrakcije u prašku vrijednosti od dva theta (CuKa niti λ = 1.5406 ? na 22 °C): 5,69; 6,76; 8,38; 11,43; 12,74; 13,62; 14,35; 15,09; 15,66; 15,43; 17,16; 17,66; 18,31; 19,03; 19,54; 20,57; 21,06; 21,; 22,31; 23,02; 23,66; 24,18; 14,98; 25,50; 26,23; 26,46; 27,59; 28,89; 29,58; 30,32; 31,0 31,52; iliOblik B karakteriziranparametrima jedinične ćelije koji su jednaki slijedećemDimenzije ćelije a = 16,675(2) ? b = 28,083(4) ? c = 6,054(1) ? Volumen = 2835(1) ?3 Prostorna skupina P212121 OrtorombnaMolekule/jedinična ćelija 4Gustoća (izračunana) (g/cm3) 1,184Točka taljenja 191 - 199 °C (razlaganje); ikarakteristični pikovi (vršne vrijednosti) u uzorcima rentgenske difrakcije u prašku pri vrijednosti od dva theta (CuKa niti λ = 1.5406 ? na 22 °C): 6,17; 10,72; 12,33; 14,17; 14,93, 15,88; 16,17; 17,11; 17,98; 19,01; 19,61; 20,38; 21,55; 21,73; 22,48; 23,34; 23,93; 24,78, 25,15; 25,90; 26,63; 27,59; 28,66; 29,55; 30,49 i 31,22. Patent sadrži još 20 patentnih zahtjeva.
There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAK8PeJ9PUPCvAIVvB3U3D0U3AN8A_x8PTx93MF8hx9_N15GFjTEnOKU3mhNDeDkptriLOHbmpBfnxqcUFicmpeakm8R1CAkYGBsYGhpYGToTFRigCFeSMJ</recordid><startdate>20110731</startdate><enddate>20110731</enddate><creator>VITEZ IMRE M</creator><creator>FAVREAU DENIS</creator><creator>ZHENRONG GUO</creator><creator>DAVIDOVICH MARTHA</creator><creator>DIMARCO JOHN D</creator><creator>MALLOY TIMOTHY M</creator><creator>GOUGOUTAS JACK Z</creator><creator>GALELLA MICHAEL</creator><scope>EVB</scope></search><sort><creationdate>20110731</creationdate><title>POLYMORPHS OF AN EPOTHILONE ANALOG</title><author>VITEZ IMRE M ; FAVREAU DENIS ; ZHENRONG GUO ; DAVIDOVICH MARTHA ; DIMARCO JOHN D ; MALLOY TIMOTHY M ; GOUGOUTAS JACK Z ; GALELLA MICHAEL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HRP20030190B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>hrv ; eng</language><creationdate>2011</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>VITEZ IMRE M</creatorcontrib><creatorcontrib>FAVREAU DENIS</creatorcontrib><creatorcontrib>ZHENRONG GUO</creatorcontrib><creatorcontrib>DAVIDOVICH MARTHA</creatorcontrib><creatorcontrib>DIMARCO JOHN D</creatorcontrib><creatorcontrib>MALLOY TIMOTHY M</creatorcontrib><creatorcontrib>GOUGOUTAS JACK Z</creatorcontrib><creatorcontrib>GALELLA MICHAEL</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VITEZ IMRE M</au><au>FAVREAU DENIS</au><au>ZHENRONG GUO</au><au>DAVIDOVICH MARTHA</au><au>DIMARCO JOHN D</au><au>MALLOY TIMOTHY M</au><au>GOUGOUTAS JACK Z</au><au>GALELLA MICHAEL</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>POLYMORPHS OF AN EPOTHILONE ANALOG</title><date>2011-07-31</date><risdate>2011</risdate><abstract>Kristalni polimorf analoga epotilona prikazan formulomnaznačen time, što sadrži Oblik A karakteriziran: parametrima jedinične ćelije koji su jednaki slijedećem: Dimenzije ćelije a = 14,152(6) ? b = 30,72(2) ? c = 6,212(3) ? Volumen = 2701 (4) ?3 Prostorna skupina P212121 OrtorombnaMolekula/jedinična ćelija 4Gustoća (izračunata) (g/cm3) 1,247Točka taljenja 182 - 185 °C (razlaganje); ikarakteristični pikovi (vršne vrijednosti) u uzorcima rentgenske difrakcije u prašku vrijednosti od dva theta (CuKa niti λ = 1.5406 ? na 22 °C): 5,69; 6,76; 8,38; 11,43; 12,74; 13,62; 14,35; 15,09; 15,66; 15,43; 17,16; 17,66; 18,31; 19,03; 19,54; 20,57; 21,06; 21,; 22,31; 23,02; 23,66; 24,18; 14,98; 25,50; 26,23; 26,46; 27,59; 28,89; 29,58; 30,32; 31,0 31,52; iliOblik B karakteriziranparametrima jedinične ćelije koji su jednaki slijedećemDimenzije ćelije a = 16,675(2) ? b = 28,083(4) ? c = 6,054(1) ? Volumen = 2835(1) ?3 Prostorna skupina P212121 OrtorombnaMolekule/jedinična ćelija 4Gustoća (izračunana) (g/cm3) 1,184Točka taljenja 191 - 199 °C (razlaganje); ikarakteristični pikovi (vršne vrijednosti) u uzorcima rentgenske difrakcije u prašku pri vrijednosti od dva theta (CuKa niti λ = 1.5406 ? na 22 °C): 6,17; 10,72; 12,33; 14,17; 14,93, 15,88; 16,17; 17,11; 17,98; 19,01; 19,61; 20,38; 21,55; 21,73; 22,48; 23,34; 23,93; 24,78, 25,15; 25,90; 26,63; 27,59; 28,66; 29,55; 30,49 i 31,22. Patent sadrži još 20 patentnih zahtjeva.
There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them.</abstract><oa>free_for_read</oa></addata></record> |
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| title | POLYMORPHS OF AN EPOTHILONE ANALOG |
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