STABLE POLYMORPH OF N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUI-NAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF
Ovaj izum odnosi se na postojan kristalni oblik N-(3-etinilfenil)-6,7-bis(2-metoksietoksi)-4-kinazolinamin hidroklorida koji je označen kao polimorfni oblik B, njegovo dobivanje u praktički čistom obliku i njegovu upotrebu. Izum se također odnosi na farmaceutske smjese koje sadrže postojan polimorfn...
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| creator | NORRIS, TYMOTHY FERRANTE, KAREN, J RAGGON, JEFFREY W MORIN, MICHAEL, J CONNELL, RICHARD, D MOYER, JAMES, D SILBERMAN, SANDRA, L KAJIJI, SHAMA MOHAMMED FOSTER, BARBARA, A |
| description | Ovaj izum odnosi se na postojan kristalni oblik N-(3-etinilfenil)-6,7-bis(2-metoksietoksi)-4-kinazolinamin hidroklorida koji je označen kao polimorfni oblik B, njegovo dobivanje u praktički čistom obliku i njegovu upotrebu. Izum se također odnosi na farmaceutske smjese koje sadrže postojan polimorfni oblik B N-(3-etinilfenil)-6,7-bis(2-metoksietoksi)-4-kinazolinamin hidroklorida, kao i ostale oblike spoja, te na metode tretiranja hiperproliferacijskih poremećaja, kao što je karcinom, primjenom toga spoja.
The invention provides a compound comprising N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, or a pharmaceutically acceptable salt thereof in anhydrous or hydrate form for use in the treatment of NSCLC (non small cell lung cancer). |
| format | Patent |
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The invention provides a compound comprising N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, or a pharmaceutically acceptable salt thereof in anhydrous or hydrate form for use in the treatment of NSCLC (non small cell lung cancer).</description><language>hrv ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SEPARATION ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; TRANSPORTING</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130228&DB=EPODOC&CC=HR&NR=P20020388B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130228&DB=EPODOC&CC=HR&NR=P20020388B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NORRIS, TYMOTHY</creatorcontrib><creatorcontrib>FERRANTE, KAREN, J</creatorcontrib><creatorcontrib>RAGGON, JEFFREY W</creatorcontrib><creatorcontrib>MORIN, MICHAEL, J</creatorcontrib><creatorcontrib>CONNELL, RICHARD, D</creatorcontrib><creatorcontrib>MOYER, JAMES, D</creatorcontrib><creatorcontrib>SILBERMAN, SANDRA, L</creatorcontrib><creatorcontrib>KAJIJI, SHAMA MOHAMMED</creatorcontrib><creatorcontrib>FOSTER, BARBARA, A</creatorcontrib><title>STABLE POLYMORPH OF N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUI-NAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF</title><description>Ovaj izum odnosi se na postojan kristalni oblik N-(3-etinilfenil)-6,7-bis(2-metoksietoksi)-4-kinazolinamin hidroklorida koji je označen kao polimorfni oblik B, njegovo dobivanje u praktički čistom obliku i njegovu upotrebu. Izum se također odnosi na farmaceutske smjese koje sadrže postojan polimorfni oblik B N-(3-etinilfenil)-6,7-bis(2-metoksietoksi)-4-kinazolinamin hidroklorida, kao i ostale oblike spoja, te na metode tretiranja hiperproliferacijskih poremećaja, kao što je karcinom, primjenom toga spoja.
The invention provides a compound comprising N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, or a pharmaceutically acceptable salt thereof in anhydrous or hydrate form for use in the treatment of NSCLC (non small cell lung cancer).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SEPARATION</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjEFOwzAQRbNhgYA7jFi1UkYKCYJuHXuiseR4XNuRMJuqQmaFoFI5D2elBQ7A5v3Ff_9fNl8pq9ERBHFllhgYZAKPqwEpc_HFBaYT1Wy9rPGhfcTRplWP86mWp_LLNd7jdrHo1bM4688yARcTRbOTaA218DMw6XwfophFZyu-BeUNBFZxVpqWbLVysCRKkJkiyXTdXLzu34715i-vmtuJsmash49dPR72L_W9fu44hr7r-m7YbMa74V_SN2_6RPw</recordid><startdate>20130228</startdate><enddate>20130228</enddate><creator>NORRIS, TYMOTHY</creator><creator>FERRANTE, KAREN, J</creator><creator>RAGGON, JEFFREY W</creator><creator>MORIN, MICHAEL, J</creator><creator>CONNELL, RICHARD, D</creator><creator>MOYER, JAMES, D</creator><creator>SILBERMAN, SANDRA, L</creator><creator>KAJIJI, SHAMA MOHAMMED</creator><creator>FOSTER, BARBARA, A</creator><scope>EVB</scope></search><sort><creationdate>20130228</creationdate><title>STABLE POLYMORPH OF N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUI-NAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF</title><author>NORRIS, TYMOTHY ; FERRANTE, KAREN, J ; RAGGON, JEFFREY W ; MORIN, MICHAEL, J ; CONNELL, RICHARD, D ; MOYER, JAMES, D ; SILBERMAN, SANDRA, L ; KAJIJI, SHAMA MOHAMMED ; FOSTER, BARBARA, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HRP20020388B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>hrv ; eng</language><creationdate>2013</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SEPARATION</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>NORRIS, TYMOTHY</creatorcontrib><creatorcontrib>FERRANTE, KAREN, J</creatorcontrib><creatorcontrib>RAGGON, JEFFREY W</creatorcontrib><creatorcontrib>MORIN, MICHAEL, J</creatorcontrib><creatorcontrib>CONNELL, RICHARD, D</creatorcontrib><creatorcontrib>MOYER, JAMES, D</creatorcontrib><creatorcontrib>SILBERMAN, SANDRA, L</creatorcontrib><creatorcontrib>KAJIJI, SHAMA MOHAMMED</creatorcontrib><creatorcontrib>FOSTER, BARBARA, A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NORRIS, TYMOTHY</au><au>FERRANTE, KAREN, J</au><au>RAGGON, JEFFREY W</au><au>MORIN, MICHAEL, J</au><au>CONNELL, RICHARD, D</au><au>MOYER, JAMES, D</au><au>SILBERMAN, SANDRA, L</au><au>KAJIJI, SHAMA MOHAMMED</au><au>FOSTER, BARBARA, A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>STABLE POLYMORPH OF N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUI-NAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF</title><date>2013-02-28</date><risdate>2013</risdate><abstract>Ovaj izum odnosi se na postojan kristalni oblik N-(3-etinilfenil)-6,7-bis(2-metoksietoksi)-4-kinazolinamin hidroklorida koji je označen kao polimorfni oblik B, njegovo dobivanje u praktički čistom obliku i njegovu upotrebu. Izum se također odnosi na farmaceutske smjese koje sadrže postojan polimorfni oblik B N-(3-etinilfenil)-6,7-bis(2-metoksietoksi)-4-kinazolinamin hidroklorida, kao i ostale oblike spoja, te na metode tretiranja hiperproliferacijskih poremećaja, kao što je karcinom, primjenom toga spoja.
The invention provides a compound comprising N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, or a pharmaceutically acceptable salt thereof in anhydrous or hydrate form for use in the treatment of NSCLC (non small cell lung cancer).</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEPARATION SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRANSPORTING |
| title | STABLE POLYMORPH OF N-(3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUI-NAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF |
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