PROPHYLACTIC AND THERAPEUTIC USE OF MURAMYL PEPTIDES AND THEIR ANALOGUES AGAINST VIRAL INFECTIONS
1. A pharmaceutical composition for enteral or parenteral application, which composition contains, as sole active ingredient, an effective amount, but less than 1 % by weight, of a compound of the formula I see diagramm : EP0102319,P31,F1 in which the sugar moiety is derived from (D)-galactose, (D)-...
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| creator | LUKAS, BOHUMIR SCHMIDT-RUPPIN, KARL HEINZ |
| description | 1. A pharmaceutical composition for enteral or parenteral application, which composition contains, as sole active ingredient, an effective amount, but less than 1 % by weight, of a compound of the formula I see diagramm : EP0102319,P31,F1 in which the sugar moiety is derived from (D)-galactose, (D)-mannose or (D)-glucose, which compound has at an asymmetrically substituted C(-R**3) atom the (D)-configuration, at an asymmetrically substituted C(-R**6) atom the (L)-configuration and at an asymmetrically substituted C(-R**8) atom the (D)-configuration, and in which compound each of X**1 and X**2 independently to the other represents a group of the formula -O- or -N(R**14)-, R**14 representing hydrogen or lower alkyl, each of R**1, R**2, R**12 and R**13 independently represents a radical of the formula Ia -(Z**1-Y**1-X**3)n -A**1 in which n represents 0 or 1, Z**1 represents carbonyl or thiocarbonyl, Y**1 represents unsubstituted or substituted alkylene which may be interrupted by iminocarbonyl or oxycarbonyl, X**3 represents a group of the formula -O- or -N(R**14)-, wherein R**14 has the meaning given above, and A**1 represents a radical of the formula Ib see diagramm : EP0102319,P31,F2 in which R**15 represents an aliphatic or cycloaliphatic radical having at least 7 carbon atoms, or A**1 represents a group of the formula Ic see diagramm : EP0102319,P31,F3 in which R**16 represents hydrogen and R**17 represents 2-hydroxyethyl or 1,2-dihydroxyethyl, wherein at least one hydroxy group is esterified or etherified by a radical having at least 7 carbon atoms, or in which each or R**16 and R**17 independently of the other represents esterified or etherified hydroxymethyl, the esterifying or etherifying radicals having at least 7 carbon atoms, or each of R**1, R**2, R**12 and R**13 independently represents hydrogen, acyl other than a radical of the formula Ia in which n represents 1, or aliphatically substituted silyl, each of R**3, R**4, R**5, R**7 and R**8 independently represents hydrogen or lower alkyl, R**6 represents hydrogen or lower alkyl that is unsubstituted or substituted by a group of the formula Id -E-(Z**2-Y**2-X**4)m -A**2 in which m represents 0 or 1, E represents a group of the formula -O-, -S- or -N(R**14), R**14 having the meaning given above, Z**2 represents carbonyl or thiocarbonyl, Y**2 represents unsubstituted or substituted alkylene which may be interrupted by iminocarbonyl or oxycarbonyl, X**4 represents a group of the formula -O- or -N(R** |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_HK79890A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>HK79890A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_HK79890A3</originalsourceid><addsrcrecordid>eNrjZEgMCPIP8Ij0cXQO8XRWcPRzUQjxcA1yDHANBfFDg10V_N0UfEODHH0jfRQCXANCPF1cg2HqPIOALEcff_dQkJi7o6dfcIhCmGeQo4-Cp5-bK9BIf79gHgbWtMSc4lReKM3NIOvmGuLsoZtakB-fWlyQmJyal1oS7-FtbmlhaeBoTEgeAD8qMlU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PROPHYLACTIC AND THERAPEUTIC USE OF MURAMYL PEPTIDES AND THEIR ANALOGUES AGAINST VIRAL INFECTIONS</title><source>esp@cenet</source><creator>LUKAS, BOHUMIR ; SCHMIDT-RUPPIN, KARL HEINZ</creator><creatorcontrib>LUKAS, BOHUMIR ; SCHMIDT-RUPPIN, KARL HEINZ</creatorcontrib><description>1. A pharmaceutical composition for enteral or parenteral application, which composition contains, as sole active ingredient, an effective amount, but less than 1 % by weight, of a compound of the formula I see diagramm : EP0102319,P31,F1 in which the sugar moiety is derived from (D)-galactose, (D)-mannose or (D)-glucose, which compound has at an asymmetrically substituted C(-R**3) atom the (D)-configuration, at an asymmetrically substituted C(-R**6) atom the (L)-configuration and at an asymmetrically substituted C(-R**8) atom the (D)-configuration, and in which compound each of X**1 and X**2 independently to the other represents a group of the formula -O- or -N(R**14)-, R**14 representing hydrogen or lower alkyl, each of R**1, R**2, R**12 and R**13 independently represents a radical of the formula Ia -(Z**1-Y**1-X**3)n -A**1 in which n represents 0 or 1, Z**1 represents carbonyl or thiocarbonyl, Y**1 represents unsubstituted or substituted alkylene which may be interrupted by iminocarbonyl or oxycarbonyl, X**3 represents a group of the formula -O- or -N(R**14)-, wherein R**14 has the meaning given above, and A**1 represents a radical of the formula Ib see diagramm : EP0102319,P31,F2 in which R**15 represents an aliphatic or cycloaliphatic radical having at least 7 carbon atoms, or A**1 represents a group of the formula Ic see diagramm : EP0102319,P31,F3 in which R**16 represents hydrogen and R**17 represents 2-hydroxyethyl or 1,2-dihydroxyethyl, wherein at least one hydroxy group is esterified or etherified by a radical having at least 7 carbon atoms, or in which each or R**16 and R**17 independently of the other represents esterified or etherified hydroxymethyl, the esterifying or etherifying radicals having at least 7 carbon atoms, or each of R**1, R**2, R**12 and R**13 independently represents hydrogen, acyl other than a radical of the formula Ia in which n represents 1, or aliphatically substituted silyl, each of R**3, R**4, R**5, R**7 and R**8 independently represents hydrogen or lower alkyl, R**6 represents hydrogen or lower alkyl that is unsubstituted or substituted by a group of the formula Id -E-(Z**2-Y**2-X**4)m -A**2 in which m represents 0 or 1, E represents a group of the formula -O-, -S- or -N(R**14), R**14 having the meaning given above, Z**2 represents carbonyl or thiocarbonyl, Y**2 represents unsubstituted or substituted alkylene which may be interrupted by iminocarbonyl or oxycarbonyl, X**4 represents a group of the formula -O- or -N(R**14)-, having the meaning given above, and A**2 represents a radical of the formula Ib or lc ; or by free or etherified hydroxy or mercapto, by esterified hydroxy or mercapto other than a group of the formula Id, by free amino or substituted amino other than a group of the formula Id, by free, esterified or amidated carboxy, by cycloalkyl, by carbocyclic aryl or by nitrogen-containing heteroaryl having 5 or 6 ring members in the heterocyclic ring, or R**5 and R**6 together represent unsubstituted 1,3- or 1,4-lower alkylene, each of R**9 and R**11 independently of the other represents a radical of the formula Ie -X**5-Y**3-X**6-A**3 in which X**5 represents a group of the formula -O-, -S- or -N(R**14)-, and X**6 represents a group of the formula -O- or -N(R**14)-, in each case R**14 having the meaning given above, Y**3 represents unsubstituted or substituted alkylene which may be interrupted by iminocarbonyl or oxycarbonyl, and A**3 represents a radical of the formula Id or lc, or free hydroxy or mercapto, etherified hydroxy or mercapto other than a radical of the formula Ie, or free amino or substituted amino other than a radical of the formula Ie, and represents hydrogen or free, esterified or amidated carboxy, with the proviso that radicals qualified by the term "lower" contain up to and including 7 carbon atoms and that the compounds of the formula I have at least one radical A**1, A**2 or A**3 and/or a pharmaceutically acceptable salt thereof, together with a pharmaceutical carrier.</description><edition>4</edition><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1990</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19901012&DB=EPODOC&CC=HK&NR=79890A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19901012&DB=EPODOC&CC=HK&NR=79890A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LUKAS, BOHUMIR</creatorcontrib><creatorcontrib>SCHMIDT-RUPPIN, KARL HEINZ</creatorcontrib><title>PROPHYLACTIC AND THERAPEUTIC USE OF MURAMYL PEPTIDES AND THEIR ANALOGUES AGAINST VIRAL INFECTIONS</title><description>1. A pharmaceutical composition for enteral or parenteral application, which composition contains, as sole active ingredient, an effective amount, but less than 1 % by weight, of a compound of the formula I see diagramm : EP0102319,P31,F1 in which the sugar moiety is derived from (D)-galactose, (D)-mannose or (D)-glucose, which compound has at an asymmetrically substituted C(-R**3) atom the (D)-configuration, at an asymmetrically substituted C(-R**6) atom the (L)-configuration and at an asymmetrically substituted C(-R**8) atom the (D)-configuration, and in which compound each of X**1 and X**2 independently to the other represents a group of the formula -O- or -N(R**14)-, R**14 representing hydrogen or lower alkyl, each of R**1, R**2, R**12 and R**13 independently represents a radical of the formula Ia -(Z**1-Y**1-X**3)n -A**1 in which n represents 0 or 1, Z**1 represents carbonyl or thiocarbonyl, Y**1 represents unsubstituted or substituted alkylene which may be interrupted by iminocarbonyl or oxycarbonyl, X**3 represents a group of the formula -O- or -N(R**14)-, wherein R**14 has the meaning given above, and A**1 represents a radical of the formula Ib see diagramm : EP0102319,P31,F2 in which R**15 represents an aliphatic or cycloaliphatic radical having at least 7 carbon atoms, or A**1 represents a group of the formula Ic see diagramm : EP0102319,P31,F3 in which R**16 represents hydrogen and R**17 represents 2-hydroxyethyl or 1,2-dihydroxyethyl, wherein at least one hydroxy group is esterified or etherified by a radical having at least 7 carbon atoms, or in which each or R**16 and R**17 independently of the other represents esterified or etherified hydroxymethyl, the esterifying or etherifying radicals having at least 7 carbon atoms, or each of R**1, R**2, R**12 and R**13 independently represents hydrogen, acyl other than a radical of the formula Ia in which n represents 1, or aliphatically substituted silyl, each of R**3, R**4, R**5, R**7 and R**8 independently represents hydrogen or lower alkyl, R**6 represents hydrogen or lower alkyl that is unsubstituted or substituted by a group of the formula Id -E-(Z**2-Y**2-X**4)m -A**2 in which m represents 0 or 1, E represents a group of the formula -O-, -S- or -N(R**14), R**14 having the meaning given above, Z**2 represents carbonyl or thiocarbonyl, Y**2 represents unsubstituted or substituted alkylene which may be interrupted by iminocarbonyl or oxycarbonyl, X**4 represents a group of the formula -O- or -N(R**14)-, having the meaning given above, and A**2 represents a radical of the formula Ib or lc ; or by free or etherified hydroxy or mercapto, by esterified hydroxy or mercapto other than a group of the formula Id, by free amino or substituted amino other than a group of the formula Id, by free, esterified or amidated carboxy, by cycloalkyl, by carbocyclic aryl or by nitrogen-containing heteroaryl having 5 or 6 ring members in the heterocyclic ring, or R**5 and R**6 together represent unsubstituted 1,3- or 1,4-lower alkylene, each of R**9 and R**11 independently of the other represents a radical of the formula Ie -X**5-Y**3-X**6-A**3 in which X**5 represents a group of the formula -O-, -S- or -N(R**14)-, and X**6 represents a group of the formula -O- or -N(R**14)-, in each case R**14 having the meaning given above, Y**3 represents unsubstituted or substituted alkylene which may be interrupted by iminocarbonyl or oxycarbonyl, and A**3 represents a radical of the formula Id or lc, or free hydroxy or mercapto, etherified hydroxy or mercapto other than a radical of the formula Ie, or free amino or substituted amino other than a radical of the formula Ie, and represents hydrogen or free, esterified or amidated carboxy, with the proviso that radicals qualified by the term "lower" contain up to and including 7 carbon atoms and that the compounds of the formula I have at least one radical A**1, A**2 or A**3 and/or a pharmaceutically acceptable salt thereof, together with a pharmaceutical carrier.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1990</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZEgMCPIP8Ij0cXQO8XRWcPRzUQjxcA1yDHANBfFDg10V_N0UfEODHH0jfRQCXANCPF1cg2HqPIOALEcff_dQkJi7o6dfcIhCmGeQo4-Cp5-bK9BIf79gHgbWtMSc4lReKM3NIOvmGuLsoZtakB-fWlyQmJyal1oS7-FtbmlhaeBoTEgeAD8qMlU</recordid><startdate>19901012</startdate><enddate>19901012</enddate><creator>LUKAS, BOHUMIR</creator><creator>SCHMIDT-RUPPIN, KARL HEINZ</creator><scope>EVB</scope></search><sort><creationdate>19901012</creationdate><title>PROPHYLACTIC AND THERAPEUTIC USE OF MURAMYL PEPTIDES AND THEIR ANALOGUES AGAINST VIRAL INFECTIONS</title><author>LUKAS, BOHUMIR ; SCHMIDT-RUPPIN, KARL HEINZ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HK79890A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1990</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LUKAS, BOHUMIR</creatorcontrib><creatorcontrib>SCHMIDT-RUPPIN, KARL HEINZ</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LUKAS, BOHUMIR</au><au>SCHMIDT-RUPPIN, KARL HEINZ</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROPHYLACTIC AND THERAPEUTIC USE OF MURAMYL PEPTIDES AND THEIR ANALOGUES AGAINST VIRAL INFECTIONS</title><date>1990-10-12</date><risdate>1990</risdate><abstract>1. A pharmaceutical composition for enteral or parenteral application, which composition contains, as sole active ingredient, an effective amount, but less than 1 % by weight, of a compound of the formula I see diagramm : EP0102319,P31,F1 in which the sugar moiety is derived from (D)-galactose, (D)-mannose or (D)-glucose, which compound has at an asymmetrically substituted C(-R**3) atom the (D)-configuration, at an asymmetrically substituted C(-R**6) atom the (L)-configuration and at an asymmetrically substituted C(-R**8) atom the (D)-configuration, and in which compound each of X**1 and X**2 independently to the other represents a group of the formula -O- or -N(R**14)-, R**14 representing hydrogen or lower alkyl, each of R**1, R**2, R**12 and R**13 independently represents a radical of the formula Ia -(Z**1-Y**1-X**3)n -A**1 in which n represents 0 or 1, Z**1 represents carbonyl or thiocarbonyl, Y**1 represents unsubstituted or substituted alkylene which may be interrupted by iminocarbonyl or oxycarbonyl, X**3 represents a group of the formula -O- or -N(R**14)-, wherein R**14 has the meaning given above, and A**1 represents a radical of the formula Ib see diagramm : EP0102319,P31,F2 in which R**15 represents an aliphatic or cycloaliphatic radical having at least 7 carbon atoms, or A**1 represents a group of the formula Ic see diagramm : EP0102319,P31,F3 in which R**16 represents hydrogen and R**17 represents 2-hydroxyethyl or 1,2-dihydroxyethyl, wherein at least one hydroxy group is esterified or etherified by a radical having at least 7 carbon atoms, or in which each or R**16 and R**17 independently of the other represents esterified or etherified hydroxymethyl, the esterifying or etherifying radicals having at least 7 carbon atoms, or each of R**1, R**2, R**12 and R**13 independently represents hydrogen, acyl other than a radical of the formula Ia in which n represents 1, or aliphatically substituted silyl, each of R**3, R**4, R**5, R**7 and R**8 independently represents hydrogen or lower alkyl, R**6 represents hydrogen or lower alkyl that is unsubstituted or substituted by a group of the formula Id -E-(Z**2-Y**2-X**4)m -A**2 in which m represents 0 or 1, E represents a group of the formula -O-, -S- or -N(R**14), R**14 having the meaning given above, Z**2 represents carbonyl or thiocarbonyl, Y**2 represents unsubstituted or substituted alkylene which may be interrupted by iminocarbonyl or oxycarbonyl, X**4 represents a group of the formula -O- or -N(R**14)-, having the meaning given above, and A**2 represents a radical of the formula Ib or lc ; or by free or etherified hydroxy or mercapto, by esterified hydroxy or mercapto other than a group of the formula Id, by free amino or substituted amino other than a group of the formula Id, by free, esterified or amidated carboxy, by cycloalkyl, by carbocyclic aryl or by nitrogen-containing heteroaryl having 5 or 6 ring members in the heterocyclic ring, or R**5 and R**6 together represent unsubstituted 1,3- or 1,4-lower alkylene, each of R**9 and R**11 independently of the other represents a radical of the formula Ie -X**5-Y**3-X**6-A**3 in which X**5 represents a group of the formula -O-, -S- or -N(R**14)-, and X**6 represents a group of the formula -O- or -N(R**14)-, in each case R**14 having the meaning given above, Y**3 represents unsubstituted or substituted alkylene which may be interrupted by iminocarbonyl or oxycarbonyl, and A**3 represents a radical of the formula Id or lc, or free hydroxy or mercapto, etherified hydroxy or mercapto other than a radical of the formula Ie, or free amino or substituted amino other than a radical of the formula Ie, and represents hydrogen or free, esterified or amidated carboxy, with the proviso that radicals qualified by the term "lower" contain up to and including 7 carbon atoms and that the compounds of the formula I have at least one radical A**1, A**2 or A**3 and/or a pharmaceutically acceptable salt thereof, together with a pharmaceutical carrier.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PROPHYLACTIC AND THERAPEUTIC USE OF MURAMYL PEPTIDES AND THEIR ANALOGUES AGAINST VIRAL INFECTIONS |
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