ANTIGEN-BINDING POLYPEPTIDE CONSTRUCTS COMPRISING KAPPA AND LAMBDA LIGHT CHAINS AND USES THEREOF
Provided herein are multispecific antigen-binding polypeptide constructs comprising at least two different heterodimers, each comprising a heavy chain and a light chain. At least one heterodimer comprises a Fab region comprising a lambda light chain and at least one heterodimer comprises a Fab regio...
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| creator | PRESTA, Leonard G TOM-YEW, Stacey A.L SANCHES, Mario UROSEV, Dunja |
| description | Provided herein are multispecific antigen-binding polypeptide constructs comprising at least two different heterodimers, each comprising a heavy chain and a light chain. At least one heterodimer comprises a Fab region comprising a lambda light chain and at least one heterodimer comprises a Fab region comprising a kappa light chain. One or more of the immunoglobulin heavy and light chains that form the antigen-binding polypeptide construct comprise amino acid modifications that promote correct pairing between the heavy and light chains to form the desired multispecific antigen-binding polypeptide construct. The amino acid modifications may be in the CH1 and/or CL domains, in the VH and/or VL domains, or a combination thereof. |
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At least one heterodimer comprises a Fab region comprising a lambda light chain and at least one heterodimer comprises a Fab region comprising a kappa light chain. One or more of the immunoglobulin heavy and light chains that form the antigen-binding polypeptide construct comprise amino acid modifications that promote correct pairing between the heavy and light chains to form the desired multispecific antigen-binding polypeptide construct. 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The amino acid modifications may be in the CH1 and/or CL domains, in the VH and/or VL domains, or a combination thereof.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNijsOgkAQQGksjHqHuQAFErUedgd2Ag4bdiiskJi1MkqC94-feACr9_LylskZRbkiSQsWy1KBb5uTJ69sCUwrQbveaHjr0XccPkeN3iOgWGjwWFiEhiunYByyhG_vAwVQRx215TpZXMfbHDc_rhIoSY1L4_QY4jyNl3iPz8HV2Xa3zw45Zvkfywsr9zL8</recordid><startdate>20190913</startdate><enddate>20190913</enddate><creator>PRESTA, Leonard G</creator><creator>TOM-YEW, Stacey A.L</creator><creator>SANCHES, Mario</creator><creator>UROSEV, Dunja</creator><scope>EVB</scope></search><sort><creationdate>20190913</creationdate><title>ANTIGEN-BINDING POLYPEPTIDE CONSTRUCTS COMPRISING KAPPA AND LAMBDA LIGHT CHAINS AND USES THEREOF</title><author>PRESTA, Leonard G ; TOM-YEW, Stacey A.L ; SANCHES, Mario ; UROSEV, Dunja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HK1256173A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>PRESTA, Leonard G</creatorcontrib><creatorcontrib>TOM-YEW, Stacey A.L</creatorcontrib><creatorcontrib>SANCHES, Mario</creatorcontrib><creatorcontrib>UROSEV, Dunja</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PRESTA, Leonard G</au><au>TOM-YEW, Stacey A.L</au><au>SANCHES, Mario</au><au>UROSEV, Dunja</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTIGEN-BINDING POLYPEPTIDE CONSTRUCTS COMPRISING KAPPA AND LAMBDA LIGHT CHAINS AND USES THEREOF</title><date>2019-09-13</date><risdate>2019</risdate><abstract>Provided herein are multispecific antigen-binding polypeptide constructs comprising at least two different heterodimers, each comprising a heavy chain and a light chain. 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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | ANTIGEN-BINDING POLYPEPTIDE CONSTRUCTS COMPRISING KAPPA AND LAMBDA LIGHT CHAINS AND USES THEREOF |
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