ACE2 POLYPEPTIDE
Recombinant angiotensin I converting enzyme 2 (ACE2) polypeptide, where at least 80% of the possible N-glycosylation position of the polypeptide is glycosylated and the polypeptide shows a sugar portion of greater than 10% (mass-%, relative to the total ACE2-molecule), preferably greater than 20%, i...
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| creator | STRANNER, Stefan WAGNER, Bettina SCHUSTER, Manfred JANZEK-HAWLAT, Evelyne WEIK, Robert LOIBNER, Hans PEBALL, Bernhard |
| description | Recombinant angiotensin I converting enzyme 2 (ACE2) polypeptide, where at least 80% of the possible N-glycosylation position of the polypeptide is glycosylated and the polypeptide shows a sugar portion of greater than 10% (mass-%, relative to the total ACE2-molecule), preferably greater than 20%, is new. Independent claims are included for: (1) a preparation comprising the recombinant ACE2 polypeptide, where the portion of ACE2 polypeptide with a molecular weight of under 100 kDa, preferably under 119 kDa, lies under 20%, preferably 0%; (2) ACE2 polypeptide or the preparation having a catalytic activity (Kcat) of at least 4/s, preferably 7.6/s for the conversion to angiotensin 1-7; (3) preparing recombinant ACE2 polypeptide or the preparation; and (4) a stable eukaryotic cell line transfected with an ACE2 coding polynucleotide, preferably Chinese hamster ovary (CHO) cells line, which expresses ACE2 polypeptide. ACTIVITY : Respiratory-Gen. MECHANISM OF ACTION : None given. |
| format | Patent |
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Independent claims are included for: (1) a preparation comprising the recombinant ACE2 polypeptide, where the portion of ACE2 polypeptide with a molecular weight of under 100 kDa, preferably under 119 kDa, lies under 20%, preferably 0%; (2) ACE2 polypeptide or the preparation having a catalytic activity (Kcat) of at least 4/s, preferably 7.6/s for the conversion to angiotensin 1-7; (3) preparing recombinant ACE2 polypeptide or the preparation; and (4) a stable eukaryotic cell line transfected with an ACE2 coding polynucleotide, preferably Chinese hamster ovary (CHO) cells line, which expresses ACE2 polypeptide. ACTIVITY : Respiratory-Gen. MECHANISM OF ACTION : None given.</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190816&DB=EPODOC&CC=HK&NR=1255493A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190816&DB=EPODOC&CC=HK&NR=1255493A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>STRANNER, Stefan</creatorcontrib><creatorcontrib>WAGNER, Bettina</creatorcontrib><creatorcontrib>SCHUSTER, Manfred</creatorcontrib><creatorcontrib>JANZEK-HAWLAT, Evelyne</creatorcontrib><creatorcontrib>WEIK, Robert</creatorcontrib><creatorcontrib>LOIBNER, Hans</creatorcontrib><creatorcontrib>PEBALL, Bernhard</creatorcontrib><title>ACE2 POLYPEPTIDE</title><description>Recombinant angiotensin I converting enzyme 2 (ACE2) polypeptide, where at least 80% of the possible N-glycosylation position of the polypeptide is glycosylated and the polypeptide shows a sugar portion of greater than 10% (mass-%, relative to the total ACE2-molecule), preferably greater than 20%, is new. Independent claims are included for: (1) a preparation comprising the recombinant ACE2 polypeptide, where the portion of ACE2 polypeptide with a molecular weight of under 100 kDa, preferably under 119 kDa, lies under 20%, preferably 0%; (2) ACE2 polypeptide or the preparation having a catalytic activity (Kcat) of at least 4/s, preferably 7.6/s for the conversion to angiotensin 1-7; (3) preparing recombinant ACE2 polypeptide or the preparation; and (4) a stable eukaryotic cell line transfected with an ACE2 coding polynucleotide, preferably Chinese hamster ovary (CHO) cells line, which expresses ACE2 polypeptide. ACTIVITY : Respiratory-Gen. MECHANISM OF ACTION : None given.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBBwdHY1Ugjw94kMcA0I8XRx5WFgTUvMKU7lhdLcDApuriHOHrqpBfnxqcUFicmpeakl8R7ehkampiaWxo6GxkQoAQC_mxz_</recordid><startdate>20190816</startdate><enddate>20190816</enddate><creator>STRANNER, Stefan</creator><creator>WAGNER, Bettina</creator><creator>SCHUSTER, Manfred</creator><creator>JANZEK-HAWLAT, Evelyne</creator><creator>WEIK, Robert</creator><creator>LOIBNER, Hans</creator><creator>PEBALL, Bernhard</creator><scope>EVB</scope></search><sort><creationdate>20190816</creationdate><title>ACE2 POLYPEPTIDE</title><author>STRANNER, Stefan ; WAGNER, Bettina ; SCHUSTER, Manfred ; JANZEK-HAWLAT, Evelyne ; WEIK, Robert ; LOIBNER, Hans ; PEBALL, Bernhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HK1255493A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>STRANNER, Stefan</creatorcontrib><creatorcontrib>WAGNER, Bettina</creatorcontrib><creatorcontrib>SCHUSTER, Manfred</creatorcontrib><creatorcontrib>JANZEK-HAWLAT, Evelyne</creatorcontrib><creatorcontrib>WEIK, Robert</creatorcontrib><creatorcontrib>LOIBNER, Hans</creatorcontrib><creatorcontrib>PEBALL, Bernhard</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>STRANNER, Stefan</au><au>WAGNER, Bettina</au><au>SCHUSTER, Manfred</au><au>JANZEK-HAWLAT, Evelyne</au><au>WEIK, Robert</au><au>LOIBNER, Hans</au><au>PEBALL, Bernhard</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ACE2 POLYPEPTIDE</title><date>2019-08-16</date><risdate>2019</risdate><abstract>Recombinant angiotensin I converting enzyme 2 (ACE2) polypeptide, where at least 80% of the possible N-glycosylation position of the polypeptide is glycosylated and the polypeptide shows a sugar portion of greater than 10% (mass-%, relative to the total ACE2-molecule), preferably greater than 20%, is new. Independent claims are included for: (1) a preparation comprising the recombinant ACE2 polypeptide, where the portion of ACE2 polypeptide with a molecular weight of under 100 kDa, preferably under 119 kDa, lies under 20%, preferably 0%; (2) ACE2 polypeptide or the preparation having a catalytic activity (Kcat) of at least 4/s, preferably 7.6/s for the conversion to angiotensin 1-7; (3) preparing recombinant ACE2 polypeptide or the preparation; and (4) a stable eukaryotic cell line transfected with an ACE2 coding polynucleotide, preferably Chinese hamster ovary (CHO) cells line, which expresses ACE2 polypeptide. ACTIVITY : Respiratory-Gen. MECHANISM OF ACTION : None given.</abstract><oa>free_for_read</oa></addata></record> |
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| language | chi ; eng |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | ACE2 POLYPEPTIDE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T13%3A05%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=STRANNER,%20Stefan&rft.date=2019-08-16&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EHK1255493A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |