HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS D1

The present invention provides D1 agonists with reduced D1R desensitization, D1 agonists with a reduced ²-arrestin recruitment activity relative to Dopamine, D1 agonists interacting significantly with the Ser188 but not significantly with the Ser202 of a D1R when binding to the D1R, D1 agonists inte...

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Hauptverfasser:	MENTE, SCOT, RICHARD SR, SUBRAMANYAM, CHAKRAPANI C, NASON, DEANE, MILFORD, II DM, ALLEN, JOHN, ARTHUR JA, GUILMETTE, EDWARD, RAYMOND ER, EFREMOV, IVAN, VIKTOROVICH IV, GRAY, DAVID, LAWRENCE, FIRMAN DLF, COE, JOTHAM, WADSWORTH JW, XU, WENJIAN, HELAL, CHRISTOPHER, JOHN CJ, DAVOREN, JENNIFER, ELIZABETH JE, HARRIS, ANTHONY, RICHARD AR, DOUNAY, AMY, BETH AB, ONEIL, STEVEN, VICTOR SV, HENDERSON, JACLYN, LOUISE JL
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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