CRYSTALLINE AND NON-CRYSTALLINE FORMS OF TOFACITINIB, AND A PHARMACEUTICAL COMPOSITION COMPRISING TOFACITINIB AND A PENETRATION ENHANCER

CRYSTALLINE AND NON-CRYSTALLINE FORMS OF TOFACITINIB, AND A PHARMACEUTICAL COMPOSITION COMPRISING TOFACITINIB AND A PENETRATION ENHANCER

The present invention discloses novel crystalline and non-crystalline forms of 3-((3R,4R)-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-pip-eridin-1-yl)-3-oxopropionitrile, pharmaceutical composition containing the same, preparations thereof and the uses thereof.

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Bibliographische Detailangaben
Hauptverfasser: JOHNSON, PHILLIP J. PJ, WHITE, TIMOTHY, D. TD, CHEKAL, BRIAN P. BP, MARGULIS, LEONID A. LA, FOTI, CHRISTOPHER JAMES CJ, MURPHY, BRENDAN J. BJ
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention discloses novel crystalline and non-crystalline forms of 3-((3R,4R)-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-pip-eridin-1-yl)-3-oxopropionitrile, pharmaceutical composition containing the same, preparations thereof and the uses thereof.