A PROCESS FOR THE PREPARATION OF THE COMPOUND AND SYNTHETIC INTERMEDIATES THEREOF

A PROCESS FOR THE PREPARATION OF THE COMPOUND AND SYNTHETIC INTERMEDIATES THEREOF

A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously desc...

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Hauptverfasser: LIVI, VALERIA, SPINELLI, SILVANO
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Sprache:chi ; eng
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator LIVI, VALERIA
SPINELLI, SILVANO
description A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title A PROCESS FOR THE PREPARATION OF THE COMPOUND AND SYNTHETIC INTERMEDIATES THEREOF
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