SINGLE-CHAIN, MULTIPLE ANTIGEN FORMING MOLECULE, ITS MANUFACTURE AND USE
Single-chain molecule (I) that binds multiple antigens comprises two variable domains of heavy immunoglobulin chains (VH), having specificities A and B and two variable domains of light chains (VL), also with specificities A and B. The domains are provided as two VH-VL constructs which are attached...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | SEDLACEK, HANS-HARALD KONTERMANN, ROLAND MÜLLER, ROLF |
| description | Single-chain molecule (I) that binds multiple antigens comprises two variable domains of heavy immunoglobulin chains (VH), having specificities A and B and two variable domains of light chains (VL), also with specificities A and B. The domains are provided as two VH-VL constructs which are attached via a peptide (P). Any VH and VL may be replaced by their functional fragments. Independent claims are also included for the following: (1) nucleic acid (II) encoding (I); (2) vectors containing (II); (3) cells containing (II) or the vectors; (4) recombinant production of (I) by culturing these cells; (5) pharmaceutical composition containing (I), (II), the vectors or cells; and (6) diagnostic composition containing (I). ACTIVITY : Anticancer; antiviral; antibacterial; antimalarial; antiinflammatory. MECHANISM OF ACTION : Specific binding interaction. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_HK1130498A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>HK1130498A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_HK1130498A13</originalsourceid><addsrcrecordid>eNrjZPAI9vRz93HVdfZw9PTTUfAN9QnxDPBxVXD0C_F0d_VTcPMP8gWqUPD193F1DvVx1VHwDAlW8HX0C3VzdA4JDQKpdFEIDXblYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxHt6GhsYGJpYWjobGRCgBAJa5LDY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>SINGLE-CHAIN, MULTIPLE ANTIGEN FORMING MOLECULE, ITS MANUFACTURE AND USE</title><source>esp@cenet</source><creator>SEDLACEK, HANS-HARALD ; KONTERMANN, ROLAND ; MÜLLER, ROLF</creator><creatorcontrib>SEDLACEK, HANS-HARALD ; KONTERMANN, ROLAND ; MÜLLER, ROLF</creatorcontrib><description>Single-chain molecule (I) that binds multiple antigens comprises two variable domains of heavy immunoglobulin chains (VH), having specificities A and B and two variable domains of light chains (VL), also with specificities A and B. The domains are provided as two VH-VL constructs which are attached via a peptide (P). Any VH and VL may be replaced by their functional fragments. Independent claims are also included for the following: (1) nucleic acid (II) encoding (I); (2) vectors containing (II); (3) cells containing (II) or the vectors; (4) recombinant production of (I) by culturing these cells; (5) pharmaceutical composition containing (I), (II), the vectors or cells; and (6) diagnostic composition containing (I). ACTIVITY : Anticancer; antiviral; antibacterial; antimalarial; antiinflammatory. MECHANISM OF ACTION : Specific binding interaction.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20091231&DB=EPODOC&CC=HK&NR=1130498A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20091231&DB=EPODOC&CC=HK&NR=1130498A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SEDLACEK, HANS-HARALD</creatorcontrib><creatorcontrib>KONTERMANN, ROLAND</creatorcontrib><creatorcontrib>MÜLLER, ROLF</creatorcontrib><title>SINGLE-CHAIN, MULTIPLE ANTIGEN FORMING MOLECULE, ITS MANUFACTURE AND USE</title><description>Single-chain molecule (I) that binds multiple antigens comprises two variable domains of heavy immunoglobulin chains (VH), having specificities A and B and two variable domains of light chains (VL), also with specificities A and B. The domains are provided as two VH-VL constructs which are attached via a peptide (P). Any VH and VL may be replaced by their functional fragments. Independent claims are also included for the following: (1) nucleic acid (II) encoding (I); (2) vectors containing (II); (3) cells containing (II) or the vectors; (4) recombinant production of (I) by culturing these cells; (5) pharmaceutical composition containing (I), (II), the vectors or cells; and (6) diagnostic composition containing (I). ACTIVITY : Anticancer; antiviral; antibacterial; antimalarial; antiinflammatory. MECHANISM OF ACTION : Specific binding interaction.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAI9vRz93HVdfZw9PTTUfAN9QnxDPBxVXD0C_F0d_VTcPMP8gWqUPD193F1DvVx1VHwDAlW8HX0C3VzdA4JDQKpdFEIDXblYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxHt6GhsYGJpYWjobGRCgBAJa5LDY</recordid><startdate>20091231</startdate><enddate>20091231</enddate><creator>SEDLACEK, HANS-HARALD</creator><creator>KONTERMANN, ROLAND</creator><creator>MÜLLER, ROLF</creator><scope>EVB</scope></search><sort><creationdate>20091231</creationdate><title>SINGLE-CHAIN, MULTIPLE ANTIGEN FORMING MOLECULE, ITS MANUFACTURE AND USE</title><author>SEDLACEK, HANS-HARALD ; KONTERMANN, ROLAND ; MÜLLER, ROLF</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_HK1130498A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2009</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SEDLACEK, HANS-HARALD</creatorcontrib><creatorcontrib>KONTERMANN, ROLAND</creatorcontrib><creatorcontrib>MÜLLER, ROLF</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SEDLACEK, HANS-HARALD</au><au>KONTERMANN, ROLAND</au><au>MÜLLER, ROLF</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SINGLE-CHAIN, MULTIPLE ANTIGEN FORMING MOLECULE, ITS MANUFACTURE AND USE</title><date>2009-12-31</date><risdate>2009</risdate><abstract>Single-chain molecule (I) that binds multiple antigens comprises two variable domains of heavy immunoglobulin chains (VH), having specificities A and B and two variable domains of light chains (VL), also with specificities A and B. The domains are provided as two VH-VL constructs which are attached via a peptide (P). Any VH and VL may be replaced by their functional fragments. Independent claims are also included for the following: (1) nucleic acid (II) encoding (I); (2) vectors containing (II); (3) cells containing (II) or the vectors; (4) recombinant production of (I) by culturing these cells; (5) pharmaceutical composition containing (I), (II), the vectors or cells; and (6) diagnostic composition containing (I). ACTIVITY : Anticancer; antiviral; antibacterial; antimalarial; antiinflammatory. MECHANISM OF ACTION : Specific binding interaction.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_HK1130498A1 |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | SINGLE-CHAIN, MULTIPLE ANTIGEN FORMING MOLECULE, ITS MANUFACTURE AND USE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T09%3A25%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SEDLACEK,%20HANS-HARALD&rft.date=2009-12-31&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EHK1130498A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |